Application of quantitative estimates of fecal hemoglobin concentration for risk prediction of colorectal neoplasia

Table 1 Quality measures of the colorectal cancer screening program in this study

Quality indicator	Outcomes	1Standard	Quality
Colonoscopy attendance rate	63.10%	≥ 85%	Inadequate
Cecum intubation rate	98.10%	≥ 90%	Adequate
Polyp detection rate	57.20%	-	-
Adenoma detection rate	35.70%	≥ 35%	Adequate
Cancer detection rate	2.7‰ screened by FIT	≥ 2‰ screened by fecal occult blood test	Auditable outcome
	3.9% screening colonoscopies	≥ 11% screening colonoscopies
Major bleeding	0.24%	< 1%	Adequate
Perforation	0	< 1‰	Adequate

¹NHS BCSP quality assurance guidelines for colonoscopy 2011. NHS: National Health Service; BCSP: bowel cancer screening program.

Table 2 Age, gender, and fecal immunochemical test concentration in association with histological grade of colorectal tumor: multiple linear regression analysis

1Multiple linear regression model		Beta (95%CI)	P value
Age (yr)	50-69	0.021 (0.012-0.030)	< 0.001
Gender	Female: 0, Male: 1	0.342 (0.245-0.44)	< 0.001
2FIT (ngHb/mL)	Scale 1: 12.1-25	0.088 (0.062-0.114)	< 0.001
	Scale 2: 25.1-50
	Scale 3: 50.1-100
	Scale 4: 100.1-200
	Scale 5: 200.1-400
	Scale 6: 400.1-800
	Scale 7: > 800

¹The model revealed a significant association between histological grade of colorectal tumors and three independent variables: age, gender and FIT concentrations;

²We converted the continuous FIT value into an ordinal variable after a log(2) transformation of the FIT concentrations. FIT: Fecal immunochemical test.