Magnifying endoscopy for the diagnosis of specialized intestinal metaplasia in short-segment Barrett’s esophagus

Table 1 Individual results

Patient	Type	Stain	Histology	Reflux	Patient	Type	Stain	Histology	Reflux
1	Villous	Yes	SIM	Yes	16	Tubular	No	Insufficiency	Yes
2	Oval	No	Cardiac	No	17	Villous	Yes	SIM	Yes
3	Oval	No	Cardiac	No	18	Oval	No	Fundic	Yes
4	Straight	No	Fundic	No	19	Tubular	No	Insufficiency	No
5	Straight	Yes	Fundic	No	20	Oval	Yes	Fundic	Yes
6	Tubular	No	Cardiac	No	21	Villous	Yes	SIM	No
7	Oval	No	Cardiac	No	22	Tubular	No	Insufficiency	No
8	Tubular	Yes	Cardiac	No	23	Tubular	Yes	Cardiac	Yes
9	Tubular	No	Cardiac	No	24	Villous	Yes	Cardiac	Yes
10	Small round	Yes	Fundic	No	25	Oval	No	Cardiac	Yes
11	Tubular	No	Cardiac	Yes	26	Villous	No	Cardiac	No
12	Tubular	No	Cardiac	No	27	Straight	No	Cardiac	No
13	Tubular	No	Fundic	No	28	Tubular	No	Cardiac	No
14	Tubular	Yes	Insufficiency	No	29	Oval	Yes	Cardiac	Yes
15	Tubular	Yes	Cardiac	No	30	Oval	yes	Cardiac	Yes

SIM: Specialized intestinal metaplasia.

Table 2 Relationship between specialized intestinal metaplasia and variables

Variables	SIM (+)	SIM (-)	Total
Reflux esophagitis	2	9	11
No-Reflux esophagitis	1	14	15
Total1	3	23	26
Villous	3	2	5
Non-villous	0	21	21
Total2	3	23	26
MB stain	3	9	12
Non-MB stain	0	14	14
Total3	3	23	26

¹Fisher’s exact test: P = 0.538;

²Sensitivity = 100%, specificity = 91.3%, accuracy = 92.3%, PPV = 60%, NPV =100%, Fisher’s exact test: P = 0.004;

³Sensitivity = 100%, specificity = 60.9%, accuracy = 65.4%, PPV = 25%, NPV = 100%, Fisher’s exact test: P = 0.085. SIM: Specialized intestinal metaplasia; PPV: Positive predictive value; NPV: Negative predictive value; MB: Methylene blue.

Table 3 Diagnostic value of pit-pattern evaluation and metaplasia staining for detection of specialized intestinal metaplasia (n = 3)

	TP	TN	P value
Pit-pattern	3	21
MB stain	3	14
	Pit-pattern	MB stain
Sensitivity	100.00%	100.00%
Specificity	91.30%	60.90%	0.03911
Accuracy	92.30%	65.40%	0.03911
PPV	60.00%	25.00%	0.16431
NPV	100.00%	100.00%

¹P value by exact McNemar’s test. TP: True positive; TN: True negative; PPV: Positive predictive value; NPV: Negative predictive value; MB: Methylene blue.