Role of Ki-67 as a prognostic factor in gastrointestinal stromal tumors

Table 1 Patient distribution according to sex and age in three different groups

Groups		Sex		Total
		Male	Female
Localized disease	Number	19	17	36
	Average age (yr)	59.5	62.9	61.1
Recurrent disease	Number	17	12	29
	Average age (yr)	55.5	58.4	56.7
Metastatic disease	Number	20	15	35
	Average	60.7	48.7	55.5
Total	Number	56	44	100
	Average age (yr)	58.7	56.8	57.9

Table 2 Multivariate analysis of different parameters for survival in all analyzed patients (n =100)

Parameter	Beta	Standard error	t value	P value
Tumor size	0.04	0.03	1.12	0.26
Mitosis	-0.01	0.01	-0.91	0.35
Necrosis	0.76	0.73	1.04	0.29
Haemorrhage	-0.63	0.68	-0.93	0.35
Ki-67	0.05	0.02	1.83	0.06
c-KIT	1.44	0.79	1.83	0.06
SMA	0.19	0.51	0.38	0.70
S100	-0.33	0.67	-0.49	0.62
CD34	-0.34	0.52	-0.66	0.50
Cell morphology	-0.19	0.52	-0.37	0.70

SMA: Smooth muscle actin.

Table 3 Multivariate analysis of different parameters for the disease free interval in patients with initially localized disease (n = 65)

Parameter	Beta	Standard error	t value	Exponent beta	P value
Tumor size	0.052	0.031	1.643	1.053	0.100
Number of mitosis	0.011	0.014	0.797	1.011	0.424
Necrosis	0.525	0.633	0.830	1.691	0.406
Haemorrhage	0.865	0.673	1.285	2.377	0.198
Ki-67	0.113	0.030	3.778	1.120	0.0001
c-KIT	0.592	0.536	1.102	1.807	0.270
SMA	-1.213	0.575	-2.110	0.297	0.034
S100	-0.237	0.771	-0.308	0.788	0.757
CD34	-1.088	0.562	-1.935	0.336	0.052

SMA: Smooth muscle actin.