Effect of alcohol consumption on liver stiffness measured by transient elastography

Table 1 Initial and final biological parameters and transient elastography and of patients according to their alcohol consumption status

	Abstinent (n = 13)		Relapser (n = 24)
	Initial	Final	Initial	Final
Normal AST	8%	75%	8%	15%
AST (IU/L)	130 (39-374)	42 (15-118)	140 (16-472)	119 (17-749)
ALT (IU/L)	109 (34-387)	44 (13-163)	88 (18-266)	76 (9-329)
GGT (IU/L)	1414 (121-3405)	301 (17-1040)	874 (48-5749)	536 (53-1858)
GGT (kPa)	15.5 (10.9-24.3)	11.7 (4.8-22.5)	11.7 (4-34.8)	13.5 (4.2-26.4)
Age, yr	48 ± 9		44 ± 10
Sex (M/F)	11/2		4/20

Data are expressed by median (quartile range) and mean ± SD. ALT: Alanine amino transferase; AST: Aspartate aminotransferase; GGT: Gamma glutamyltranspeptidase; M: Male; F: Female.

Table 2 Transient elastography and histological results of patient with liver biopsy

Patient	TEi (kPa)	EASL stage	Liver biopsy initial	TEf (kPa)	EASL stage	Liver biopsy final	Alcohol status
1	33.8	F4		26.4	F4	F4	Relapser
2	34.8	F4		75	F4	F4	Relapser
3	10.2	F3	F4	20.6	F4		Relapser
4	21.3	F4		14	F4	F3	Relapser
5	9.9	F3	F1	4.6	F ≤ 2		Relapser
6	5.3	F ≤ 2		16.9	F4	F3	Relapser
7	20.3	F4		14.3	F4	F4	Abstinent
8	11.7	F3		13.6	F4	F4	Abstinent

Data are shown in chronological order. EASL: European Association for the Study of Liver; TEi: Transient elastography initial; TEf: Transient elastography final.

Table 3 Percent of abstinent and relapser patient presenting a variation of Metavir score at the end of follow-up according to transient elastography using different cut off values

	Cut-off value	Increase in one or more stage of liver fibrosis (%)	Stable (%)	Decrease in one or more stage of liver fibrosis (%)
Abstinents	EASL	7	36	57
	Nguyen	7	22	71
	Nahon	7	65	28
Relapsers	EASL	29	55	16
	Nguyen	33	30	37
	Nahon	16	72	12

Results are expressed as percent of patient for each class. EASL: European Association for the Study of Liver.