Personalizing therapies for gastric cancer: Molecular mechanisms and novel targeted therapies

Table 1 Selected clinical trials of trastuzumab in gastro-esophageal cancer

Ref.	Phase	Treatment	n	OS (mo)	PFS (mo)	RR	CR	PR
Bang et al[73]	III	5-FU + cisplatin or capecitabine + cisplatin	290	11.1	5.5	34.50%	NA	NA
		Trastuzumab + 5-FU + cisplatin or trastuzumab + capecitabine + cisplatin	294	13.8	6.7	47.30%	NA	NA
Cortés-Funes et al[67]	II	Trastuzumab + cisplatin	21	NA	NA	41.10%	5.80%	35.00%
Egamberdiev et al[68]	II	Trastuzumab + leucovirin + cisplatin + 5-FU	16	NA	8.3	54.50%	NA	NA
		Leucovirin + cisplatin + 5-FU	18	NA	5.2	33.30%	NA	NA
Grávalos et al[69]	II	Trastuzumab + cisplatin	22	NA	5.1	32.00%	NA	NA

OS: Overall survival; PFS: Progression-free survival; 5-FU: 5-fluorouracil; RR: Response rate; CR: Complete response; PR: Partial response; NA: Not available.

Table 2 Clinical trials with trastuzumab-based combination therapies

Setting, therapy line	ID	Phase	n	Treatment combined with trastuzumab	Primary EP	Status
Operable disease	NCT01196390	III	480	Carboplatin, paclitaxel, radical radiotherapy	PFS	Recruiting
	NCT01472029	II	53	5-FU, leucovorin, docetaxel, oxaliplatin	Rate of CR	Recruiting
	NCT01130337	II	45	Oxaliplatin, capecitabine	PFS	Active, not recruiting
Advanced first line	NCT01450696	III	400	Cisplatin, capecitabine	OS	Recruiting
	NCT01503983	II	51	Oxaliplatin, capecitabine	OS	Recruiting
	NCT01461057	II	30	Cisplatin, capecitabine, pertuzumab	Safety	Active, not recruiting
	NCT01396707	II	56	Oxaliplatin, capecitabine	RR	Recruiting
	NCT01364493	II	51	Oxaliplatin, capecitabine	RR	Recruiting
	NCT01359397	II	80	Docetaxel, oxaliplatin, capecitabine, bevacizumab	PFS	Recruiting
	NCT01228045	II	30	Cisplatin, S-1	RR	Unknown
	NCT01191697	II	36	Oxaliplatin, capecitabine, bevacizumab	RR	Recruiting
Advanced second line	NCT01402401	II	48	AUY922	RR	Terminated

ID, NCT identification (information available at http://clinicaltrials.gov, as accessed June 28, 2013). OS: Overall survival; PFS: Progression-free survival; 5-FU: 5-fluorouracil; RR: Response rate; CR: Complete response; PR: Partial response; NA: Not available.

Table 3 Clinical trials with other anti-human epidermal growth factor receptor 2 agents

Setting, therapy line	ID	Phase	n	Treatment	Primary EP	Status
Operable disease	NCT00450203	III	370	Lapatinib, epirubicin, cisplatin, capecitabine	OS	Recruiting
Advanced first line	NCT00680901	III	535	Lapatinib, oxaliplatin, capecitabine	OS	Active, not recruiting
	LOGiC
	NCT01395537	II	43	Lapatinib, carboplatin, paclitaxel	Safety, RR	Active, not recruiting
	NCT01123473	II	192	Lapatinib, epirubicin, cisplatin, capecitabine, 5-FU	PFS	Unknown
	NCT00526669	II	67	Lapatinib, capecitabine	RR	Active, not recruiting
Advanced second line	NCT00486954	III	273	Lapatinib, paclitaxel	OS	Completed
	TYTAN
	NCT01522768	II	27	Afatinib	RR	Recruiting
	NCT01152853	II	28	Dacomitinib	PFS	Unknown
	NCT01145404	II	76	Lapatinib, capecitabine	RR	Active, not recruiting

OS: Overall survival; PFS: Progression-free survival; 5-FU: 5-fluorouracil; RR: Response rate; CR: Complete response; PR: Partial response; NA: Not available.