Fatty acids of erythrocyte membrane in acute pancreatitis patients

doi:10.3748/wjg.v19.i34.5678

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 14, 2013; 19(34): 5678-5684
Published online Sep 14, 2013. doi: 10.3748/wjg.v19.i34.5678

Table 1 Demographic and clinical data of patients and controls

	AP	Severe AP	Mild AP	Control
Age, mean ± SD, yr	48.1 ± 15.5	50.2 ± 13.7	46.7 ± 16.8	42.07 ± 16.6
Men	68%	64%	70%	33%
AP etiology
Alcoholic	35%	36%	35%	NA
Nonalcoholic	65%	64%	65%	NA
Death	6%	7%	5%	NA

Values are percentage unless otherwise stated. NA: Not applicable; AP: Acute pancreatitis.

Table 2 Percentages of saturated, monounsaturated and polyunsaturated fatty acids in erythrocyte membrane phospholipids

	AP	Alcoholic AP	Nonalcoholic AP	Control
Saturated fatty acid
C14:0	0.26 ± 0.06	0.26 ± 0.06	0.26 ± 0.07	0.27 ± 0.06
C15:0	0.29 ± 0.05	0.27 ± 0.04	0.30 ± 0.06	0.30 ± 0.05
C16:0	23.43 ± 1.12^b	23.80 ± 1.20^b	23.22 ± 1.06^b	22.17 ± 0.85
C17:0	0.27 ± 0.06^b	0.23 ± 0.03^b	0.29 ± 0.06	0.31 ± 0.03
C18:0	13.49 ± 0.70^a	13.40 ± 0.54	13.54 ± 0.78	13.95 ± 0.70
C20:0	0.33 ± 0.10^b	0.28 ± 0.06^b	0.36 ± 0.09	0.40 ± 0.06
C21:0	0.04 ± 0.04	0.04 ± 0.06	0.04 ± 0.04	0.03 ± 0.03
C22:0	1.39 ± 0.33	1.15 ± 0.23^b	1.47 ± 0.34	1.44 ± 0.26
C23:0	0.21 ± 0.06^a	0.17 ± 0.04^b	0.23 ± 0.06	0.24 ± 0.04
C24:0	4.44 ± 0.80	4.30 ± 0.77	4.41 ± 0.97	4.10 ± 0.73
Total	44.05 ± 1.47^a	43.90 ± 1.00	44.13 ± 1.70	43.34 ± 0.90
Monounsaturated fatty acid
C16:1n7trans	0.13 ± 0.02	0.12 ± 0.02	0.13 ± 0.02	0.14 ± 0.02
C16:1n9c	0.09 ± 0.06^b	0.09 ± 0.03	0.09 ± 0.07	0.06 ± 0.03
C16:1n7c	0.56 ± 0.19^b	0.68 ± 0.17^b	0.49 ± 0.17^b	0.33 ± 0.06
C18:1n9trans	0.11 ± 0.05^b	0.10 ± 0.02^b	0.12 ± 0.06^a	0.16 ± 0.04
C18:1n7trans	0.28 ± 0.09^a	0.23 ± 0.07^b	0.30 ± 0.09	0.33 ± 0.09
C18:1n9c	13.02 ± 1.49	13.53 ± 1.05^a	12.85 ± 1.88	12.42 ± 1.12
C18:1n7c	1.08 ± 0.17	1.09 ± 0.15	1.07 ± 0.20	1.03 ± 0.13
C22:1n9c	0.22 ± 0.05^a	0.23 ± 0.06^a	0.22 ± 0.05^a	0.18 ± 0.05
C24:1	4.98 ± 0.69	4.86 ± 0.63	4.87 ± 0.86	4.58 ± 0.67
Total	20.49 ± 1.98^a	20.9 3± 1.13^a	20.16 ± 2.29	19.31 ± 1.02
PUFA
Omega 3 PUFA	7.84 ± 1.71^b	7.92 ± 1.74^a	7.80 ± 1.74^b	9.45 ± 1.30
C18:3n3	0.16 ± 0.05	0.18 ± 0.06	0.14 ± 0.04	0.15 ± 0.03
C20:5n3	0.91 ± 0.46	0.94 ± 0.46	0.82 ± 0.42	1.02 ± 0.4
C22:5n3	2.21 ± 0.33^a	2.29 ± 0.36	2.17 ± 0.32^a	2.39 ± 0.29
C22:6n3	4.61 ± 1.12^b	4.50 ± 1.12^b	4.67 ± 1.14^b	5.89 ± 0.81
Omega 6 PUFA	26.99 ± 1.99	26.89 ± 1.40	27.51 ± 2.17	27.93 ± 1.58
C18:2n6c	10.16 ± 1.24	10.07 ± 1.01	10.43 ± 1.43	10.18 ± 1.27
C18:3n6	0.05 ± 0.02^b	0.05 ± 0.02^b	0.04 ± 0.02^a	0.03 ± 0.01
C20:3n6	1.44 ± 0.26^a	1.49 ± 0.27	1.41 ± 0.25	1.32 ± 0.34
C20:4n6	12.94 ± 1.06^a	12.82 ± 0.82^a	13.01 ± 1.18^a	13.64 ± 0.99
C22:4n6	2.48 ± 0.58	2.46 ± 0.35	2.62 ± 0.60	2.63 ± 0.50
C16:3n4	0.05 ± 0.02^a	0.04 ± 0.02^b	0.06 ± 0.02	0.06 ± 0.02
C20:2	0.28 ± 0.06^a	0.27 ± 0.05	0.29 ± 0.06^a	0.25 ± 0.03
C22:2	0.05 ± 0.02	0.05 ± 0.01	0.06 ± 0.02	0.05 ± 0.02
Total PUFA	35.51 ± 1.95^b	35.17 ± 1.37^b	35.71 ± 2.21^b	37.34 ± 1.30

Results are presented as mean ± SD. Percentages of saturated, monounsaturated and polyunsaturated fatty acids (PUFA) in erythrocyte membrane phospholipids in patients with acute pancreatitis (AP) of alcoholic and nonalcoholic etiology.

^aP < 0.05,

^bP < 0.01 vs control group.

Table 3 Percentages of fatty acids

	Nonalcoholic		Control
	Severe AP	Mild AP
C20:0	0.32 ± 0.09^d	0.39 ± 0.09	Control	0.40 ± 0.06
C20:4n6	12.89 ± 0.83^c	13.09 ± 1.40	13.64 ± 0.99
SFA	43.53 ± 1.29	44.54 ± 1.86^c	43.34 ± 0.90
C18:3n6	0.04 ± 0.02	0.05 ± 0.02^c	0.03 ± 0.01
C18:1n9t	0.13 ± 0.04	0.12 ± 0.07^d	0.16 ± 0.04
C20:5n3	1.03 ± 0.56	0.67 ± 0.18^d	1.02 ± 0.4
C22:5n3	2.28 ± 0.22	2.10 ± 0.36^c	2.39 ± 0.29
C22:6n3	5.29 ± 1.02	4.24 ± 1.05^d	5.89 ± 0.81
n-3 PUFA	8.76 ± 1.73^a	7.14 ± 1.45^d	9.45 ± 1.30
Total PUFA	36.87 ± 1.62^a	34.91 ± 2.26^d	37.34 ± 1.30
SOD	385.37 ± 21.37^a	314.90 ± 86.04^d	384.88 ± 42.21
GPx	12557.07 ± 2836.06^a	9370.85 ± 2196.13^d	11649.09 ± 1844.75
PI	138.49 ± 10.34^a^c	128.14 ± 10.74^d	146.19 ± 7.08
UI	156.67 ± 7.28^a^c	148.99 ± 8.04^d	161.70 ± 4.90

Results are presented as mean ± SD. Percentages of fatty acids in erythrocyte membrane phospholipids, peroxidation and unsaturation indexes, and concentrations of superoxide dismutase (SOD, μmol/mL) and glutathione peroxidase (GPx, U/L) in patients with acute pancreatitis (AP) of nonalcoholic etiology.

^aP < 0.05 comparing mild and severe AP;

^cP < 0.05,

^dP < 0.01 vs control group. PUFA: Polyunsaturated fatty acids; SFA: Saturated fatty acids.

Citation: Kuliaviene I, Gulbinas A, Cremers J, Pundzius J, Kupcinskas L, Dambrauskas Z, Jansen E. Fatty acids of erythrocyte membrane in acute pancreatitis patients. World J Gastroenterol 2013; 19(34): 5678-5684
URL: https://www.wjgnet.com/1007-9327/full/v19/i34/5678.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i34.5678