HMGB1 gene polymorphisms in patients with chronic hepatitis B virus infection

Table 1 High mobility group box chromosomal protein 1 polymorphism (1176G/C) between various clinical subgroups infected with hepatitis B virus

	Sex	Age (yr)	Genotype			Allele frequency
	(M/F)	(mean ± SD)	GG	CC	GC	G	C
AsC (n = 199)	116/83	34.762 ± 11.282	107	9	83	0.7462	0.2538
AHB (n = 15)	11/4	30.201 ± 10.221	9	1	5
CHB (n = 929)	730/199	34.312 ± 11.549	572	33	324	0.6530	0.3470
SHB (n = 157)	129/28	39.989 ± 11.792	91	6	60	0.7707	0.2293
LC (n = 175)	142/33	41.950 ± 11.437	104	13	58	0.7600	0.2300
HCC (n = 20)	14/6	49.256 ± 12.232	10	1	9
LC + CHB (n = 1104)	872/232	35.461 ± 11.642	676	46	382	0.7853	0.2147
LC + CHB + SHB (n = 1261)	1001/260	36.001 ± 11.852	767	52	442	0.7835	0.2165

There was age difference in any two subgroups except between AsC and CHB, P < 0.05; There was sex difference between AsC and any other subgroups, P < 0.05; AsC: Asymptomatic carrier; AHB: Acute hepatitis B; CHB: Chronic hepatitis B; SHB: Severe hepatitis B; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma.

Table 2 Association between high mobility group box chromosomal protein 1 (1176G/C) single nucleotide polymorphism and hepatitis B virus infected subgroups

Subgroup	Dominant model		Recessive model		Codominant model
	P	OR (95%CI)	P	OR (95%CI)	P	OR (95%CI)
LC/CHB	0.075	0.533 (0.267-1.065)	0.945	0.988 (0.701-1.392)	0.120	0.844 (0.682-1.045)
LC/SHB	0.183	0.508 (0.188-1.376)	0.747	1.075 (0.693-1.669)	0.326	0.872 (0.664-1.146)
LC/AsC	0.168	2.320 (0.702-7.672)	0.108	1.572 (0.906-2.728)	0.011	1.571 (1.108-2.227)
AsC/SHB	0.473	1.616 (0.436-5.999)	0.489	1.204 (0.711-2.040)	0.206	1.254 (0.883-1.782)
AsC/CHB	0.238	1.660 (0.716-3.851)	0.052	1.389 (0.997-1.935)	0.007	1.354 (1.085-1.689)
SHB/CHB	0.916	1.050 (0.425-2.592)	0.474	1.137 (0.800-1.614)	0.462	1.090 (0.866-1.371)
SHB + LC/CHB + AsC	0.362	0.760 (0.421-1.371)	0.824	0.971 (0.747-1.262)	0.316	0.918 (0.777-1.085)
AsC/CHB + SHB + LC	0.330	1.505 (0.662-3.421)	0.044	1.401 (1.010-1.944)	0.010	1.329 (1.070-1.651)
AsC/CHB + LC	0.256	1.619 (0.704-3.721)	0.043	1.406 (1.011-1.956)	0.007	1.355 (1.088-1.687)

The association was analyzed by logistic regression analysis with adjustment for covariates, including age, sex, and alcohol consumption. Dominant model: GG + GC/CC, recessive model: GG/GC + CC, codominant model: GG/GC/CC; P and OR values were calculated by logistic regression. AsC: Asymptomatic carrier; AHB: Acute hepatitis B; CHB: Chronic hepatitis B; SHB: Severe hepatitis B; LC: Liver cirrhosis; OR: Odds ratio.