Helicobacter pylori tumor necrosis factor-&alpha; inducing protein promotes cytokine expression via nuclear factor-&kappa;B

doi:10.3748/wjg.v19.i3.399

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jan 21, 2013; 19(3): 399-403
Published online Jan 21, 2013. doi: 10.3748/wjg.v19.i3.399

Table 1 Cytokine levels at different times after interference of GES-1 and SGC7901 cells with 12.5 μg/mL recombinant tumor necrosis factor-α inducing protein

Groups	0 h	1 h	2 h	4 h	8 h
GES-1 (IL-1β)	0.34 + 0.04	0.88 + 0.09^a	2.07 + 0.30^a	1.35 + 0.20^a	1.41 + 0.15^a
SGC-7901 (IL-1β)	0.22 + 0.04	0.35 + 0.05	2.07 + 0.10^a	1.11 + 0.04^a	1.14 + 0.04^a
GES-1 (IL-8)	0.35 + 0.05	0.60 + 0.12^a	0.84 + 0.11^a	0.64 + 0.06^a	0.50 + 0.07^a
SGC-7901 (IL-8)	0.70 + 0.02	0.78 + 0.19	2.53 + 0.50^a	2.26 + 0.24^a	2.14 + 0.68^a
GES-1 (TNF-α)	0.39 + 0.06	0.39 + 0.07	0.72 + 0.08^a	0.53 + 0.03^a	0.51 + 0.14^a
SGC-7901 (TNF-α)	0.33 + 0.09	1.02 + 0.09^a	1.41 + 0.10^a	0.86 + 0.07^a	0.47 + 0.03^a

^aP < 0.05 vs 0 h. IL-1β: Interleukin-1β; TNF-α: Tumor necrosis factor-α.

Table 2 Cytokine levels in GES-1 and SGC7901 cells after interference with different concentrations of recombinant tumor necrosis factor-α inducing protein for 2 h

Groups	0	12.5μg/mL	25μg/mL	50μg/mL
GES-1 (IL-1β)	0.59 + 0.11	2.07 + 0.30^a	2.20 + 0.09^a	1.23 + 0.13^a
SGC-7901 (IL-1β)	0.36 + 0.01	2.07 + 0.10^a	1.22 + 0.03^a	1.02 + 0.04^a
GES-1 (IL-8)	0.39 + 0.08	0.84 + 0.11^a	0.75 + 0.09^a	0.61 + 0.15^a
SGC-7901 (IL-8)	0.78 + 0.09	2.53 + 0.50^a	1.50 + 0.16^a	1.41 + 0.14^a
GES-1 (TNF-α)	0.30 + 0.06	0.72 + 0.08^a	0.54 + 0.13^a	0.63 + 0.10^a
SGC-7901 (TNF-α)	0.26 + 0.18	1.41 + 0.10^a	0.62 + 0.07^a	0.62 + 0.02^a

^aP < 0.05 vs group 0. IL-1β: Interleukin-1β; TNF-α: Tumor necrosis factor-α.

Table 3 Effects of recombinant tumor necrosis factor-α inducing protein on the levels of interleukin-1β and tumor necrosis factor-α in SGC7901 cells under different conditions

Groups	A	B	C	D
SGC-7901 (IL-1β)	2.32 + 0.25	1.05 + 0.75^a	084 + 0.08	0.57 + 0.09
SGC-7901 (TNF-α)	1.51 + 0.64	0.72 + 0.20^a	0.43 + 0.07	0.71 + 0.23
GES-1 (IL-1β)	2.07 + 0.30	0.98 + 0.34^a	0.69 + 0.06	0.63 + 0.06
GES-1 (TNF-α)	0.81 + 0.08	0.36 + 0.03^a	0.27 + 0.03	0.29 + 0.04

^aP < 0.05 vs group A. IL-1β: Interleukin-1β; TNF-α: Tumor necrosis factor-α.

Citation: Tang CL, Hao B, Zhang GX, Shi RH, Cheng WF. Helicobacter pylori tumor necrosis factor-α inducing protein promotes cytokine expression via nuclear factor-κB. World J Gastroenterol 2013; 19(3): 399-403
URL: https://www.wjgnet.com/1007-9327/full/v19/i3/399.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i3.399