Phytoestrogens/insoluble fibers and colonic estrogen receptor &beta;: Randomized, double-blind, placebo-controlled study

doi:10.3748/wjg.v19.i27.4325

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Jul 21, 2013 (publication date) through Jan 31, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2013; 19(27): 4325-4333
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4325

Table 1 Urinary enterolignans (ng/mL) in study groups at different timepoints (mean ± SD)

	Placebo (n = 23)	ADI (n = 27)	P value
ED + ELT0	697.8 ± 963.3	410.3 ± 336.9	0.270
ED + ELT30	472.4 ± 475.5	3300.1 ± 1535.5	< 0.001
ED + ELT60	116.0 ± 235.2	327.5 ± 313.1	< 0.001

ED: Enterodiol; EL: Enterolactone; ADI: Active dietary intervention.

Table 2 T60 colonoscopy: Estrogen receptor-β and estrogen receptor-α expression values in the normal sigmoid mucosa of study groups (mean ± SD)

	Placebo (n = 23)	ADI (n = 27)	P value
ER-β protein	0.768 ± 0.10	0.822 ± 0.08	0.04
ER-β mRNA	0.994 ± 0.99	1.266 ± 1.24	0.10
ER-β protein	0.510 ± 0.11	0.490 ± 0.12	0.50
ER-β mRNA	0.139 ± 0.28	0.230 ± 0.24	0.20
ER-β/ER-α protein	1.571 ± 0.42	1.734 ± 0.20	0.07

ER: Estrogen receptor; ADI: Active dietary intervention.

Table 3 T60 colonoscopy: Labeling index (mean ± SD)

LI	Placebo (n = 23)	ADI (n = 27)	P value
ER-β	37.708 ± 5.31	39.222 ± 2.69	0.06
ER-β	20.416 ± 10.71	16.481 ± 10.67	0.20
ER-β/ER-α	2.437 ± 1.53	6.564 ± 10.04	0.06
TUNEL	31.541 ± 11.54	35.592 ± 14.97	0.07
Caspase-3	29.717 ± 7.98	32.937 ± 13.54	0.10
Ki-67	44.833 ± 10.38	53.923 ± 20.91	0.07

LI: Labeling index; ER: Estrogen receptor; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling; ADI: Active dietary intervention.

Table 4 Estrogen receptor-β and estrogen receptor-α, apoptosis and mitosis in non-recurrent patients

Non- recurrent	ER-βprotein	ER-βmRNA	ER-βLI	ER-βprotein	ER-βmRNA	ER-βLI	TUNEL LI	Caspase-3 LI	Ki-67 LI
ADI (median)	0.805	2.278	47.533	0.423	0.295	15.333	43.777	39.444	55.33
SD	0.13¹	1.19²	15.47²	0.06²	0.26	9.76	17.24³	15.6³	20.41
PL (median)	0.773	1.105	34.875	0.532	0.159	16.750	31.375	29.53	45.31
SD	0.13	1.07	16.67	0.11	0.32	8.86	12.93	9.13	11.29

¹P = 0.04,

²P = 0.02,

³P = 0.05 vs placebo group. LI: Labeling index; ER: Estrogen receptor; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling; ADI: Active dietary intervention.

Citation: Principi M, Di Leo A, Pricci M, Scavo MP, Guido R, Tanzi S, Piscitelli D, Pisani A, Ierardi E, Comelli MC, Barone M. Phytoestrogens/insoluble fibers and colonic estrogen receptor β: Randomized, double-blind, placebo-controlled study. World J Gastroenterol 2013; 19(27): 4325-4333
URL: https://www.wjgnet.com/1007-9327/full/v19/i27/4325.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i27.4325