Krüppel-like factor 8 overexpression is correlated with angiogenesis and poor prognosis in gastric cancer

Table 1 Krüppel-like factor 8 expression and clinicopathologic characteristics in gastric cancer

Variables	Cases (n)	KLF8 expression		P value
		Negative	Positive
Sex				0.856
Male	122	55	67
Female	32	15	17
Age (yr)				0.136
≤ 60	89	45	44
> 60	65	25	40
Tumor (cm)				< 0.001
≤ 5	92	53	39
> 5	62	17	45
Tumor differentiation				0.608
Well	14	8	6
Moderate	43	18	25
Poor	97	44	53
Local invasion				0.005
T1-T2	31	21	10
T3-T4	123	49	74
Regional lymph node metastasis				0.029
N0	45	26	19
N1	37	20	17
N2	33	9	24
N3	39	15	24
Distant metastasis				0.023
No	141	68	73
Yes	13	2	11
TNM stage				0.002
I	20	14	6
II	54	30	24
III	67	24	43
IV	13	2	11

TNM: Tumor node metastasis; KLF8: Krüppel-like factor 8.

Table 2 Correlations between Krüppel-like factor 8 expression and the microvessel density in gastric cancer

MVD	KLF8 expression		P value	r
	Negative	Positive
Low	54	32	< 0.001	0.392
High	16	52

KLF8: Krüppel-like factor 8; MVD: Microvessel density.

Table 3 Multivariate analysis of prognostic factors in patients with gastric cancer

Variables	Multivariate analysis
	Overall survival			Cancer-specific survival
	RR	95%CI	P value	RR	95%CI	P value
Sex	1.132	0.678-1.890	0.636	1.071	0.622-1.844	0.803
Age	0.785	0.521-1.182	0.247	0.775	0.509-1.180	0.235
Tumor size	1.219	0.794-1.872	0.365	1.220	0.790-1.886	0.370
Tumor differentiation	0.841	0.591-1.196	0.334	0.830	0.582-1.184	0.304
Local invasion	1.194	0.799-1.785	0.387	1.197	0.791-1.811	0.395
Regional lymph node metastasis	1.025	0.782-1.343	0.858	1.029	0.783-1.352	0.839
Distant metastasis	6.384	1.943-20.975	0.002	7.091	2.104-23.901	0.002
TNM stage	2.401	1.182-4.878	0.015	2.323	1.128-4.783	0.022
KLF8 expression	1.621	1.035-2.539	0.035	1.612	1.017-2.554	0.042
MVD	2.801	1.790-4.381	0.000	2.782	1.751-4.419	0.000

KLF8: Krüppel-like factor 8; MVD: Microvessel density; TNM: Tumor node metastasis.