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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 14, 2013; 19(26): 4214-4220
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4214
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4214
Table 1 Demographic and baseline characteristics of study in healthy volunteers
Variable | Group A (n = 14) | Group B (n = 14) | P value |
Age (yr) | 27.71 ± 8.56 | 32.5 ± 13.36 | 0.26 |
Sex (male) | 7 | 7 | 1 |
BMI (kg/m2) | 20.09 ± 1.41 | 20.21 ± 1.42 | 0.82 |
HAMD | 2.36 ± 1.28 | 1.71 ± 1.20 | 0.29 |
HAMA | 2.71 ± 1.73 | 3.36 ± 1.45 | 0.18 |
Cross-sectional area of the proximal stomach (cm2) | |||
200 mL | 17.13 ± 4.53 | 18.75 ± 2.30 | 0.08 |
400 mL | 29.19 ± 6.24 | 30.76 ± 6.59 | 0.95 |
600 mL | 40.92 ± 11.5 | 40.66 ± 7.28 | 0.35 |
800 mL | 46.21 ± 12.16 | 46.46 ± 6.81 | 0.24 |
Difficulty in drinking water VAS | |||
200 mL | 0.79 ± 0.58 | 1.07 ± 0.62 | 0.23 |
400 mL | 1.79 ± 0.58 | 1.86 ± 0.54 | 0.71 |
600 mL | 3.21 ± 0.80 | 3.50 ± 0.65 | 0.31 |
800 mL | 5.50 ± 0.76 | 5.43 ± 0.76 | 0.82 |
Gastric emptying | |||
5 min | 77.65% ± 6.5% | 81.46% ± 5.81% | 0.67 |
10 min | 62.61% ± 9.85% | 65.18% ± 6.77% | 0.55 |
OCTT (min) | 88.93% ± 19.03% | 81.43% ± 20.14% | 0.46 |
Plasma levels (pg/mL) | |||
MTL | 502.66 ± 127.52 | 440.85 ± 123.25 | 0.20 |
Ghrelin | 460.06 ± 146.25 | 444.94 ± 202.43 | 0.82 |
NPY | 888.88 ± 154.52 | 913.46 ± 139.32 | 0.66 |
Table 2 Effects of amitriptyline on gastrointestinal function and brain-gut peptides
Variable | Amitriptyline (n = 28) | Placebo (n = 28) | P value |
Cross-sectional area of the proximal stomach (cm2) | |||
200 mL | 16.51 ± 3.78 | 16.56 ± 3.98 | 0.97 |
400 mL | 27.14 ± 5.71 | 27.84 ± 5.95 | 0.49 |
600 mL | 34.11 ± 6.11 | 34.85 ± 6.61 | 0.39 |
800 mL | 39.58 ± 7.35 | 40.86 ± 8.45 | 0.34 |
Difficulty in drinking water VAS | |||
200 mL | 0.93 ± 0.65 | 0.96 ± 0.56 | 0.58 |
400 mL | 1.93 ± 0.46 | 1.82 ± 0.54 | 0.29 |
600 mL | 2.98 ± 0.85 | 3.57 ± 0.94 | 0.001 |
800 mL | 4.57 ± 0.98 | 5.57 ± 0.82 | 0.001 |
Gastric emptying | |||
5 min | 78.40 ± 11.71 | 78.84 ± 7.47 | 0.87 |
10 min | 66.72 ± 11.63 | 64.54 ± 10.29 | 0.47 |
OCTT (min) | 109.29 ± 29.68 | 96.61 ± 23.9 | 0.004 |
Plasma levels (pg/mL) | |||
MTL | 461.88 ± 129.66 | 473.40 ± 122.75 | 0.61 |
Ghrelin | 526.87 ± 158.44 | 442.87 ± 176.79 | 0.04 |
NPY | 965.64 ± 165.63 | 890.15 ± 131.46 | 0.03 |
Table 3 Baseline and after treatment with placebo
Variable | Baseline (n = 28) | Placebo (n = 28) | P value |
Cross-sectional area of the proximal stomach (cm2) | |||
200 mL | 17.95 ± 3.62 | 16.56 ± 3.98 | 0.19 |
400 mL | 29.97 ± 6.35 | 27.84 ± 5.95 | 0.09 |
600 mL | 40.78 ± 9.54 | 34.85 ± 6.61 | 0.06 |
800 mL | 46.34 ± 9.67 | 40.86 ± 8.45 | 0.06 |
Difficulty in drinking water VAS | |||
200 mL | 0.93 ± 0.59 | 0.96 ± 0.56 | 0.70 |
400 mL | 1.82 ± 0.54 | 1.82 ± 0.54 | 1.00 |
600 mL | 3.36 ± 0.72 | 3.57 ± 0.94 | 0.34 |
800 mL | 5.46 ± 0.73 | 5.57 ± 0.82 | 0.56 |
Gastric emptying | |||
5 min | 79.55 ± 6.35 | 78.84 ± 7.47 | 0.47 |
10 min | 63.89 ± 8.39 | 64.54 ± 10.29 | 0.79 |
OCTT (min) | 85.18 ± 19.60 | 96.61 ± 23.90 | 0.07 |
Plasma levels (pg/mL) | |||
MTL | 471.75 ± 127.02 | 473.40 ± 122.75 | 0.75 |
Ghrelin | 452.50 ± 173.46 | 442.87 ± 176.79 | 0.35 |
NPY | 901.17 ± 144.91 | 890.15 ± 131.46 | 0.12 |
Table 4 Baseline and after treatment with amitriptyline
Variable | Baseline (n = 28) | Amitriptyline (n = 28) | P value |
Cross-sectional area of the proximal stomach (cm2) | |||
200 mL | 17.95 ± 3.62 | 16.51 ± 3.78 | 0.22 |
400 mL | 29.97 ± 6.35 | 27.14 ± 5.71 | 0.09 |
600 mL | 40.78 ± 9.54 | 34.11 ± 6.11 | 0.06 |
800 mL | 46.34 ± 9.67 | 39.58 ± 7.35 | 0.06 |
Difficulty in drinking water VAS | |||
200 mL | 0.93 ± 0.59 | 0.93 ± 0.65 | 0.99 |
400 mL | 1.82 ± 0.54 | 1.93 ± 0.46 | 0.36 |
600 mL | 3.36 ± 0.72 | 2.98 ± 0.85 | 0.01 |
800 mL | 5.46 ± 0.73 | 4.57 ± 0.98 | 0.001 |
Gastric emptying | |||
5 min | 79.55 ± 6.35 | 78.40 ± 11.71 | 0.96 |
10 min | 63.89 ± 8.39 | 66.72 ± 11.63 | 0.17 |
OCTT (min) | 85.18 ± 19.60 | 109.29 ± 29.68 | 0.001 |
Plasma levels (pg/mL) | |||
MTL | 471.75 ± 127.02 | 461.88 ± 129.66 | 0.11 |
Ghrelin | 452.50 ± 173.46 | 526.87 ± 158.44 | 0.001 |
NPY | 901.17 ± 144.91 | 965.64 ± 165.63 | 0.001 |
Table 5 Adverse effects of amitriptyline and placebo
Adverse effect | Amitriptyline (n = 28) | Placebo (n = 28) |
Sleepiness | 10 | 2 |
Bitter taste | 7 | 2 |
Dry mouth | 6 | 3 |
Tired in early morning | 2 | 1 |
Dizziness | 2 | 0 |
Constipation | 1 | 1 |
- Citation: Huang W, Jiang SM, Jia L, You LQ, Huang YX, Gong YM, Wang GQ. Effect of amitriptyline on gastrointestinal function and brain-gut peptides: A double-blind trial. World J Gastroenterol 2013; 19(26): 4214-4220
- URL: https://www.wjgnet.com/1007-9327/full/v19/i26/4214.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i26.4214