Original Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 14, 2013; 19(26): 4146-4154
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4146
Table 1 Clinical characteristics of subjects in hepatitis B virus-related acute-on-chronic liver failure, chronic hepatitis B, and normal control groups n (%)
ACLF (n = 50)CHB (n = 29)NC (n = 20)
Male/female42/824/516/4
Age (yr)40.2 ± 12.034.4 ± 12.034.5 ± 9.2
ALT (IU/L)176.6 ± 430.0328.4 ± 386.822.3 ± 6.7
TBIL (μmol/L)566.3 ± 133.568.8 ± 90.912.2 ± 2.3
INR1.83 ± 0.441.09 ± 0.100.99 ± 0.03
HBeAg17 (34)18 (62.1)NA
Anti-HBe30 (60)8 (27.6)NA
HBVDNA (Log10 IU/mL)5.25 ± 1.306.11 ± 1.28NA
MELD score22.5 ± 4.74.6 ± 6.5-2.7 ± 1.9
This table shows the mean ± SD of age, alanine aminotransferase (ALT), total bilirubin (TBIL), international normalized ratio (INR), and hepatitis B virus (HBV) DNA of all patients. Model for End-stage Liver Disease (MELD) scores are shown for the HBV-related acute-on-chronic liver failure (ACLF) group, chronic hepatitis B (CHB) group, and normal control (NC) group. The proportion of patients positive for hepatitis B e antigen (HBeAg) or hepatitis B e antibody (anti-HBe) in the ACLF and CHB groups is also displayed. NA: Not available.
Table 2 Predisposing factors of hepatitis B virus-related acute-on-chronic liver failure non-survivors and survivors n (%)
Variceal bleedingInfection
DrugAlcoholIndeterminant reasons
Gastrointestinal tractUpper respiratory tractAscites
Non-survivors (n = 28)2 (7.1)5 (17. 8)4 (14.3)2 (7.1)7 (25.0)2 (7.1)8 (28.6)
Survivors (n = 22)07 (31.8)5 (22.7)05 (22.7)1 (4.5)4 (18.2)
Table 3 Clinical characteristics of non-survivors and survivors in hepatitis B virus-related acute-on-chronic liver failure group
Non-survivors (n = 28)Survivors (n = 22)P value
Male/female24/418/4ND
Age (yr)40.8 ± 11.039.5 ± 13.30.570
TBIL (μmol/L)607.6 ± 117.5513.7 ± 136.70.006
INR2.00 ± 0.441.62 ± 0.330.088
MELD scores23.7 ± 4.620.9 ± 4.40.021
This table shows the mean ± SD of age, total bilirubin (TBIL), international normalized ratio (INR) and Model for End-stage Liver Disease (MELD) scores for non-survivors and survivors in the hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) group. The P values of each parameter between groups are also displayed. ND: Not done.