Relationship between hepatocellular carcinoma and hepatitis B virus genotype with spontaneous YMDD mutations

Table 1 Patient characteristics in the hepatocellular carcinoma and liver cirrhosis groups

	HCC group	LC group	t orχ2value	P value
No. of patients	81	183
Age (yr; mean ± SD)	53.86 ± 11.05	52.66 ± 11.42	-0.797	0.426
Sex (male)	65	129	2.742	0.098
HBeAg positive	18	37	0.137	0.712
Serum HBV DNA loads (log10 copies/mL)	5.43 ± 1.16	5.25 ± 1.28	-1.077	0.283
Spontaneous YMDD mutation	13	7	11.983	0.001
Genotype C virus	33	33	15.441	0.000
Genotype B virus	47	146	13.518	0.000
Co-infected by genotype B and C viruses	1	4	-	-

HCC: Hepatocellular carcinoma; LC: Liver cirrhosis; HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus.

Table 2 Multivariate regression analysis for occurrence of hepatitis B virus-related hepatocellular carcinoma

Related factors	B	SE	Wald	P value	Exp (B)	95%CI
Sex (male)	0.749	0.353	4.500	0.034	2.114	1.059-4.224
HBV genotype C strain	0.904	0.335	7.257	0.007	2.469	1.279-4.764
Spontaneous YMDD mutation in genotype C strain	2.051	0.826	6.161	0.013	7.775	1.540-39.264

HBV: Hepatitis B virus.