Glycyrrhizic acid attenuates CCl4-induced hepatocyte apoptosis in rats via a p53-mediated pathway

Table 1 Effect of glycyrrhizic acid on plasma alanine aminotransferase and aspartate aminotransferase activity in CCl₄-induced rats

Group	ALT (U/L)	AST (U/L)
Control	42.4 ± 6.0	70.2 ± 2.3
CCl4	526.7 ± 57.2	640 ± 33.7
GA	342 ± 44.8a	462.8 ± 30.6a

^aP < 0.05 vs the carbon tetrachloride (CCl₄) group. GA: Glycyrrhizic acid; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

Table 2 Histopathological semiquantitative scores in the liver

Group	n	0	+ 1	+ 2	+ 3	+ 4	Staging scores
Control	15	15	0	0	0	0	0
CCl4	15	0	0	2	3	10	3.53 ± 0.74
GA	15	0	1	1	10	3	3.00 ± 0.76a

^aP < 0.05 vs the carbon tetrachloride (CCl₄) group. GA: Glycyrrhizic acid.