Value of circulating cell-free DNA in diagnosis of hepatocelluar carcinoma

Table 1 Relationship between expression of circulating cell-free DNA and clinicopathological features of 39 hepatocellular carcinoma patients

Observation index	No.	No. of positive cfDNA (%)	P value
Age (yr)
≤ 60	26	16 (61.5)	0.453255
> 60	13	6 (46.2)
Sex
Male	32	19 (59.4)	0.024449
Female	7	3 (42.9)
HBsAg
Positive	31	16 (51.6)	0.080857
Negative	8	6 (75)
Intrahepatic and extrahepatic metastasis
Positive	5	4 (80)	0.000242
Negative	34	18 (52.9)
Cirrhosis of liver
Positive	20	10 (50)	0.831179
Negative	19	12 (63.2)

cfDNA: Circulating cell-free DNA.

Table 2 Diagnostic value of circulating cell-free DNA, α-fetal protein and α L-fucosidase for hepatocellular carcinoma

Groups	Sensitivity	Specificity	Accuracy	Positive predictive value	Negative predictive value
cfDNA	56.4ce	95.6ce	77.4	91.7ce	71.7
	(22/39)	(43/45)	(65/84)	(22/24)	(43/60)
AFP	53.8ce	91.1ce	73.8	84.0e	69.5ce
	(21/39)	(41/45)	(62/84)	(21/25)	(41/59)
AFU	66.7e	75.6	71.4	70.3	72.3
	(26/39)	(34/45)	(60/84)	(26/37)	(34/47)
cfDNA + AFP	71.8e	86.7e	79.8	82.4	78
	(28/39)	(39/45)	(67/84)	(28/34)	(39/50)
cfDNA + AFU	87.2	71.1	78.6	72.3	86.5
	(34/39)	(32/45)	(66/84)	(34/47)	(32/37)
cfDNA + AFP + AFU	89.7a	64.4a	76.2	68.6	87.9
	(35/39)	(29/45)	(64/84)	(35/51)	(29/33)

^aP < 0.05 vs group circulating cell-free DNA (cfDNA) + α-fetal protein (AFP);

^cP < 0.05 vs group cfDNA + α L-fucosidase (AFU);

^eP < 0.05 vs group cfDNA + AFP + AFU.