Atorvastatin and rosuvastatin do not prevent thioacetamide induced liver cirrhosis in rats

Table 1 Effects of rosuvastatin and atorvastatin treatment on oxidative stress and liver fibrosis in thioacethamide-treated rats

	ALT	MDA nmole/g liver	Hydroxyproline (mg/g protein)	Fibrosis score (0-4)	Spleen weight (mg)
Rosuvastatin dose (mg/kg)
Control	59 (44, 69)	30.6 (20.5, 31.1)	2.67 (1.9, 3.3)	0	1200 (1100, 1400)
Ros 2.5	52 (47, 58)	24.1 (19.8, 33.9)	2.7 (2.2, 3.5)	0	1020 (950, 1150)
Ros 5	50 (41, 57)	31.3 (26.9, 36.7)	2.8 (2.3, 3.1)	0	1100 (950, 1300)
R 10	56 (46, 64)	33.7 (27.7, 37.8)	2.3 (1.8, 3.7)	0	1000 (800, 1200)
R 20	44 (41, 47)	29.4 (23.9, 39.6)	3.9 (2.4, 4.2)	0	1200 (900, 1200)
TAA	63 (37, 79)	48.7 (38.4, 50.2)	11.2 (4.5, 15.4)	4 (1.5, 4)	1900 (1600, 2200)
TAA + R 2.5	53 (47, 63)	22 (19, 31.2)	7.5 (3.7, 13.1)	2.5 (1, 4)	1450 (1050, 1950)
TAA + R 5	54 (48, 67)	36.5 (24.8, 52.1)	11.0 (4.7, 16.2)	3.25 (1, 4)	1230 (1000, 1350)
TAA + R 10	51 (43, 60)	37.8 (27.5, 44.9)	11.8 (8.3, 16.2)	3 (2, 4)	1200 (1100, 1500)
TAA + R 20	51.5 (48, 55)	39.2 (29.6, 46.8)	12.3 (3.1, 14.3)	3.5 (1, 4)	1050 (900, 1300)
Atorvastatin dose (mg/kg)
Control	59 (44, 69)	30.6 (20.5, 31.1)	2.67 (1.9, 3.3)	0	1200 (1100, 1400)
Ato 1	61 (55, 81)	32.8 (27.4, 33.6)	2.5 (2.1, 3.1)	0	1300 (1100, 1400)
Ato 10	56 (53, 59)	32.9 (29.1, 35.2)	3.4 (1.6, 3.7)	0	1200 (1100, 1300)
Ato 20	58 (48, 73)	30.1 (29.8, 35.3)	2.3 (1.95, 3)	0	1100 (1100, 1200)
TAA	63 (37, 79)	48.7 (38.4, 50.2)	11.2 (4.5, 15.4)	4 (1.5, 4)	1900 (1600, 2200)
TAA + Ato 1	49 (22, 70)	46.6 (35.8, 63.1)	9.1 (6.7, 16.1)	3 (2, 4)	1600 (900, 3000)
TAA + Ato 10	53 (47, 62)	43.4 (36.2, 53.1)	12.5 (6.9, 15.4)	4 (2, 4)	1500 (1400, 1700)
TAA + Ato 20	57 (43, 67)	48.2 (34.2, 58.5)	10.9 (5.3, 16.8)	4 (3, 4)	1500 (1300, 1700)

n = 7, in the groups that received thioacethamide (TAA), n = 4 in the control, rosuvastatin only treated groups and atorvastatin only treated groups. TAA, 200 mg/kg ip twice weekly for 12 wk. Rosuvastatin and atorvastatin had given daily by nasogastric gavage. Ros: Rosuvastatin; ALT:Alanine transaminase; MDA: Malondialdehyde.