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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. May 21, 2013; 19(19): 2904-2912
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2904
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2904
Table 1 Histological features of healing, morphological and functional findings and neomucosa formation
Group 1 (control) | Group2 (GH) | Group 3 (HBOT) | Group 4 (GH + HBOT) | P1(Groups 1-2) | P2(Groups 1-3) | P3(Groups 1-4) | |
Histological findings of wound healing | |||||||
Epithelialization | 0.3 | 1.3 | 1.0 | 1.7 | > 0.05 | > 0.05 | < 0.01 |
Granulation | 2.4 | 1.4 | 1.9 | 1.1 | > 0.05 | > 0.05 | > 0.05 |
Fibroblast | 1.7 | 1.8 | 2.0 | 2.4 | > 0.05 | > 0.05 | < 0.05 |
Inflammation | 1.4 | 1.1 | 1.2 | 1.2 | > 0.05 | > 0.05 | > 0.05 |
Angiogenesis | 4.4 | 7.5 | 7.2 | 8.9 | < 0.01 | < 0.01 | < 0.01 |
Collagen deposition | 0.9 | 2.2 | 1.6 | 2.6 | < 0.01 | < 0.05 | < 0.01 |
Morphological and functional findings | |||||||
Villus density | 0.2 | 1.3 | 1.1 | 2.0 | < 0.01 | < 0.01 | < 0.01 |
Villus height (μm) | 101 (70-109) | 135 (98-153) | 118 (81-129) | 153 (119-181) | < 0.05 | > 0.05 | < 0.05 |
Crypt depth (μm) | 83 (74-88) | 102 (82-114) | 93 (76-101) | 120 (101-133) | > 0.05 | > 0.05 | < 0.05 |
Goblet cells | 0.2 | 1.4 | 1.1 | 2.2 | < 0.01 | < 0.01 | < 0.01 |
Mucin | 0.2 | 1.7 | 1.2 | 2.2 | < 0.01 | < 0.01 | < 0.01 |
Table 2 The per-operative and 3-wk post-operative venous levels of like growth factor and insulin like growth factor binding protein 3 (nmol/L)
Group 1 (control) | Group 2 (GH therapy) | Group 4 (GH + HBO therapy) | P1(Groups 1-2) | P2(Groups 1-4) | |
Before the surgery | |||||
IGF-1 (nmol/L) | 445 (402-482) | 421 (405-460) | 431 (395-470) | NS | NS |
IGFBP-3 (nmol/L) | 2250 (2100-2350) | 2170 (2000-2300) | 2147 (2025-2350) | NS | NS |
After the surgery (3 wk) | |||||
IGF-1 (nmol/L) | 445 (415-500) | 799 (755-875) | 813 (775-900) | < 0.05 | < 0.05 |
IGFBP-3 (nmol/L) | 2290 (2050-2500) | 3300 (3000-3600) | 3328 (3000-3650) | < 0.05 | < 0.05 |
P | NS | < 0.05 | < 0.05 |
- Citation: Adas G, Adas M, Arikan S, Sarvan AK, Toklu AS, Mert S, Barut G, Kamali S, Koc B, Tutal F. Effect of growth hormone, hyperbaric oxygen and combined therapy on the gastric serosa. World J Gastroenterol 2013; 19(19): 2904-2912
- URL: https://www.wjgnet.com/1007-9327/full/v19/i19/2904.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i19.2904