Original Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. May 21, 2013; 19(19): 2904-2912
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2904
Table 1 Histological features of healing, morphological and functional findings and neomucosa formation
Group 1 (control)Group2 (GH)Group 3 (HBOT)Group 4 (GH + HBOT)P1(Groups 1-2)P2(Groups 1-3)P3(Groups 1-4)
Histological findings of wound healing
Epithelialization0.31.31.01.7> 0.05> 0.05< 0.01
Granulation2.41.41.91.1> 0.05> 0.05> 0.05
Fibroblast1.71.82.02.4> 0.05> 0.05< 0.05
Inflammation1.41.11.21.2> 0.05> 0.05> 0.05
Angiogenesis4.47.57.28.9< 0.01< 0.01< 0.01
Collagen deposition0.92.21.62.6< 0.01< 0.05< 0.01
Morphological and functional findings
Villus density0.21.31.12.0< 0.01< 0.01< 0.01
Villus height (μm)101 (70-109)135 (98-153)118 (81-129)153 (119-181)< 0.05> 0.05< 0.05
Crypt depth (μm)83 (74-88)102 (82-114)93 (76-101)120 (101-133)> 0.05> 0.05< 0.05
Goblet cells0.21.41.12.2< 0.01< 0.01< 0.01
Mucin0.21.71.22.2< 0.01< 0.01< 0.01
Table 2 The per-operative and 3-wk post-operative venous levels of like growth factor and insulin like growth factor binding protein 3 (nmol/L)
Group 1 (control)Group 2 (GH therapy)Group 4 (GH + HBO therapy)P1(Groups 1-2)P2(Groups 1-4)
Before the surgery
IGF-1 (nmol/L)445 (402-482)421 (405-460)431 (395-470)NSNS
IGFBP-3 (nmol/L)2250 (2100-2350)2170 (2000-2300)2147 (2025-2350)NSNS
After the surgery (3 wk)
IGF-1 (nmol/L)445 (415-500)799 (755-875)813 (775-900)< 0.05< 0.05
IGFBP-3 (nmol/L)2290 (2050-2500)3300 (3000-3600)3328 (3000-3650)< 0.05< 0.05
PNS< 0.05< 0.05