Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats

Table 1 Grouping and experimental design

Group No.	n	Group name	ASA pretreatment(mg/kg)	AP induction
1	8	Reference value	No	No
2	8	Acute pancreatitis control	No	Yes
3	8	Low-dose ASA	5	Yes
4	8	Medium-dose ASA	150	Yes
5	8	High-dose ASA	350	Yes

ASA: Acetylsalicylic acid; AP: Acute pancreatitis.

Table 2 Histopathological scores

	HD-ASA (n = 8)	MD-ASA (n = 8)	P value	LD-ASA (n = 8)	APC (n = 8)	RV (n = 8)	P value
Edema	2.13 ± 0.30	1.50 ± 0.19	0.002	2.63 ± 0.18	2.75 ± 0.16	0.25 ± 0.16	0.001
Hemorrhage	0.25 ± 0.16	0.25 ± 0.16		0.25 ± 0.16	0.63 ± 0.18	0.00 ± 0.00	0.01
Leukocyte infiltration	0.38 ± 0.18	0.38 ± 0.18		0.25 ± 0.16	0.75 ± 0.16	0.00 ± 0.00
Necrosis	1.00 ± 0.19	0.25 ± 0.16	0.007	1.00 ± 0.19	1.13 ± 0.13	0.00 ± 0.00	0.001
Fibrosis	0.75 ± 0.25	0.00 ± 0.00		0.63 ± 0.26	0.63 ± 0.18	0.00 ± 0.00
Total score	4.50 ± 0.68	2.38 ± 0.50	0.001	4.75 ± 0.49	5.88 ± 0.44	0.25 ± 0.16	0.001

ASA: Acetylsalicylic acid; RV: Reference values; APC: Acute pancreatitis control; LD: Low-dose; MD: Medium-dose; HD: High-dose.