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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 28, 2013; 19(16): 2507-2513
Published online Apr 28, 2013. doi: 10.3748/wjg.v19.i16.2507
Published online Apr 28, 2013. doi: 10.3748/wjg.v19.i16.2507
Table 1 General demographic attributes of study population
Overall | Liver | Upper functional | Upper organic | IBS | IBD | |
Total number | 443 | 188 | 73 | 41 | 105 | 36 |
Gender | ||||||
Male | 44.9% | 62.8% | 27.4% | 34.2% | 27.6% | 50% |
Female | 55.1% | 37.2% | 72.6% | 65.8% | 72.4% | 50% |
Age (yr) | ||||||
Median | 56 | 61 | 50 | 57 | 43 | 32 |
Range | 72 | 66 | 71 | 66 | 62 | 60 |
Quartiles | ||||||
14-41 | - | 4.81% | 30.1% | 24.4% | 45.6% | 55.6% |
42-56 | - | 23.5% | 28.8% | 24.4% | 28.2% | 19.4% |
57-65 | - | 38.5% | 21.9% | 12.2% | 10.7% | 8.3% |
66-86 | - | 33.2% | 19.2% | 39% | 15.5% | 16.7% |
Table 2 Prevalence of human leukocyte antigen DQ2/8 by age, gender and gastrointestinal disease
Proportion of positive subjects | Prevalence | P value | |
Overall | 196/443 | 44.2% | 0.02 |
Gender1 | |||
Male | 92/199 | 46.2% | |
Female | 104/244 | 42.6% | 0.45 |
Age (yr) | |||
14-41 | 48/108 | 44.4% | |
42-56 | 42/111 | 37.8% | |
57-65 | 53/107 | 49.5% | |
66-85 | 52/114 | 45.6% | 0.37 |
Disease groups | |||
Liver | 86/188 | 45.7% | |
Upper functional | 39/73 | 53.4% | |
Upper organic | 19/41 | 46.3% | |
IBS | 38/105 | 36.2% | |
IBD | 14/36 | 38.9% | 0.21 |
Table 3 Magnitude of associations between human leukocyte antigen positivity and specific gastrointestinal disease
Disease group | Odds ratio | 95%CI |
Overall | 1.2 | 0.96-1.6 |
Liver | 1.3 | 0.94-1.8 |
Upper functional | 1.8 | 1.1-2.9 |
Upper organic | 1.3 | 0.71-2.7 |
IBS | 0.89 | 0.57-1.4 |
IBD | 0.99 | 0.49-1.9 |
Table 4 Positive anti-tTg subject stratified by disease group
Disease group | n | Prevalence |
Liver | 0/173 | 0% |
Upper functional | 1/64 | 1.54% |
Upper organic | 0/35 | 0% |
IBS | 4/90 | 4.26% |
IBD | 0/36 | 0% |
Table 5 Prevalence of specific human leukocyte antigen DQ2/8 alleles between gastrointestinal and control populations n (%)
Overall | Gastrointestinal | Controls | Risk |
DQ2 and DQ8 | 2 (0.45) | 1 (0.2) | 1:45 |
DQ2, β1*02/*02 | 17 (3.8) | 13 (2.4) | 1:63 |
DQ8, β1*02 positive | 8 (1.8) | 4 (0.7) | 1:39 |
β2, β1*02/*02 | 11 (2.5) | 2 (0.4) | 1:16 |
DQ2, β1*02/X | 85 (19.2) | 106 (19.2) | 1:100 |
DQ8, β1*02 negative | 32 (7.2) | 36 (6.5) | 1:90 |
β2, β1*02/X | 41 (9.3) | 53 (9.7) | 1:104 |
α5 + other | 247 (55.8) | 336 (60.9) | 1:101 |
Total | 443 | 551 |
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Citation: DiGiacomo D, Santonicola A, Zingone F, Troncone E, Caria MC, Borgheresi P, Parrilli G, Ciacci C. Human leukocyte antigen
DQ2/8 prevalence in non-celiac patients with gastrointestinal diseases. World J Gastroenterol 2013; 19(16): 2507-2513 - URL: https://www.wjgnet.com/1007-9327/full/v19/i16/2507.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i16.2507