Non-invasive panel tests for gastrointestinal motility monitoring within the MARS-500 Project

Table 1 Dynamics of the body mass (kg) of the crewmembers

	Crewmember
	A	B	C	D	E	F
BDC	81.5	99.5	76.6	86.9	82.5	73.5
Exp. session 1	+3.5	-2.0	+4.3	-1.0	+0.1	+0.2
Exp. session 2	+3.3	-8.2	+4.0	-4.6	-2.0	-4.7
Exp. session 3	+1.5	-20.4	-3.8	-6.9	-1.2	-6.8
End of mission simulation	-1.1	-22.6	-5.4	-9.7	-4.0	-7.2

BDC: Baseline Data Collection.

Table 2 Gastric emptying half-times (h) evaluated by ¹³C-breath test

	Crewmember
Experimental session	A	B	C	D	E	F	mean ± SD
Solids
BDC	4.4	2.8	3.3	5.0	3.2	2.8	3.5 ± 1.0
Exp. session 1	2.7	2.7	2.2	6.2	2.9	2.9	3.2 ± 1.5
Exp. session 2	3.7	2.2	2.9	3.5	2.8	2.5	2.8 ± 0.5
Exp. session 3	4.9	2.2	2.7	4.8	3.4	2.6	3.3 ± 1.2
Liquids
BDC	2.6	2.3	2.4	3.0	2.8	1.9	2.5 ± 0.4
Exp. session 1	2.6	2.0	2.2	2.8	2.6	2.5	2.5 ± 0.3
Exp. session 2	2.6	2.1	2.7	2.6	2.6	2.5	2.5 ± 0.2
Exp. session 3	2.9	2.0	2.6	4.0	2.8	2.6	2.8 ± 0.7

BDC: Baseline Data Collection.

Table 3 Results of the fecal calprotectin test¹

	Crewmember
Experimental session	A	B	C	D	E	F
BDC	-	-	-	-	-	-
Day 130	-	+++	+	+	-	+++
Day 220	-	-/+2	-	-	+++	-/+2
Day 475	+++	-/+++2	+	-	-/+2	+++

¹Legend: (-) negative, (+) low positivity (< 15 μg/g), (++) medium positivity (15-60 μg/g), (+++) high positivity (> 60 μg/g);

²The repeated tests gave different results. BDC: Baseline Data Collection.