Curcumin attenuated paracetamol overdose induced hepatitis

Table 1 Summary of the hepatic necroinflammation score in all groups

Group	n	Hepatic necroinflammation scores
		0	1	2	3
Control	8	8	-	-	-
APAP	8	-	1	1	6
APAP + CUR 200	8	5	2	1	-
APAP + CUR 600	8	5	3	-	-

Data are expressed as the number of mice exhibiting each score of hepatic necroinflammation (n = 8). Hepatic necroinflammation score in each section was graded according to the criteria described by Brunt et al[16] from 0 to 3 as follow; Score 0: No hepatocyte injury/inflammation; Score 1: Sparse or mild focal zone 3 hepatocyte injury/inflammation; Score 2: Noticeable zone 3 hepatocyte injury/inflammation; Score 3: Severe zone 3 hepatocyte injury/inflammation. 0 = None; 1 = Mild; 2 = Moderate; 3 = Severe; APAP: N-acetyl-P-aminophenol; CUR: Curcumin.