Endoscopic ultrasound-guided elastography in the nodal staging of oesophageal cancer

Table 1 Demographic data of the cytologically confirmed benign and malignant lymph node groups n (%)

	Benign node	Malignant node
Gender	M 20:F 5	M 18:F 5
Age (mean, yr)	66.8	67.9
Oesophageal adenocarcinoma	17 (68)	16 (70)
Oesophageal squamous cancer	5 (20)	7 (30)
Gastric adenocarcinoma	2 (8)	0 (0)
Barrett’s oesophagus with HGD	1 (4)	0 (0)

HGD: High-grade dysplasia; M: Male; F: Female.

Table 2 Comparison of sensitivity, specificity, positive predictive value and negative predictive value for the ability of endoscopic ultrasound-based characteristics to differentiate benign from malignant lymph nodes (%, CI)

	Sensitivity	Specificity	PPV	NPV	Accuracy
Strain ratio	83 (61-95)	96 (80-100)	95 (75-100)	86 (67-96)	90 (77-97)
4/4 conventional criteria present	22 (07-43)	96 (80-100)	83 (36-99)	57 (41-72)	60 (45-72)
3/4 conventional criteria present	48 (27-69)	84 (64-96)	75 (45-92)	64 (45-80)	67 (52-80)
Size > 1 cm	61 (39-80)	64 (43-82)	61 (38-80)	64 (43-82)	62 (47-76)
Shape round	65 (43-84)	84 (64-96)	79 (54-94)	72 (53-87)	75 (60-86)
Clear border	56 (34-77)	68 (47-85)	62 (38-82)	63 (42-81)	62 (47-76)
Hypodense	70 (47-87)	68 (46-85)	67 (45-84)	71 (49-87)	69 (53-81)

PPV: Positive predictive value; NPV: Negative predictive value.

Table 3 The area under the curve for receiver operating curve characteristics for each endoscopic ultrasound-based modality for distinguishing benign from malignant nodes

	ROC AUC	P value1
Strain ratio	0.87 (0.75-1.00)	NA
Number of conventional criteria	0.79 (0.66-0.92)	0.2846
Size > 1cm	0.62 (0.48-0.76)	0.0078
Shape round	0.75 (0.62-0.87)	0.1329
Clear edge	0.62 (0.48-0.76)	0.0035
Hypodense	0.69 (0.55-0.82)	0.0100

¹Comparison with strain ratio. The P value determined relates to the area under the curve (AUC) of an individual characteristic compared to elastography strain ratio receiver operating characteristics (ROC) AUC. NA: Not available.