Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?

Table 1 Differential expression of neuronal precursor cell-expressed developmentally down-regulated 4-1 and phosphatase and tensin homolog at different histological gastric tissue specimens

Group	n	Age (yr)	Sex (M/F)	NEDD4-1							PTEN
				-	+	++	+++	Mean rank	Group	P value	-	+	++	+++	Mean rank	Group	P value
Normal gastric mucosa	21	50.0 ± 14.1	13/8	2	6	11	2	87.64	1 vs 2	0.567	3	10	4	4	108.26	1 vs 2	0.607
									1 vs 3	0.127						1 vs 3	0.211
									1 vs 4	0.519						1 vs 4	0.448
									1 vs 5	0.225						1 vs 5	0.001
									2 vs 3	0.399						2 vs 3	0.062
Chronic gastritis	21	54.2 ± 14.7	10/11	0	8	9	4	96.26	2 vs 4	0.983	1	10	8	2	116.21	2 vs 4,	0.185
Intestinal metaplasia	41	54.5 ± 12.4	21/20	3	6	23	9	106.16	2 vs 5	0.059	13	15	9	4	91.55	2 vs 5	0.000
Dysplasia	48	57.4 ± 12.5	26/22	4	14	19	11	95.83	3 vs 4	0.364	13	16	15	4	98.08	3 vs 4	0.535
Gastric carcinoma	50	54.0 ± 12.3	31/19	7	21	18	4	73.13	3 vs 5	0.001	30	10	9	1	65.9	3 vs 5	0.012
Overall	181	54.6 ± 13.8	101/80	16	55	80	30		4 vs 5	0.029	60	61	45	15		4 vs 5	0.001

NEDD4-1: Neuronal precursor cell-expressed developmentally down-regulated 4-1; PTEN: Phosphatase and tensin homolog.