Efficacy of endoluminal gastroplication in Japanese patients with proton pump inhibitor-resistant, non-erosive esophagitis

Table 1 Patients’ baseline characteristics

Characteristics	Value
Patients (n)	19
Age, yr (range)	53.0 ± 4.3 (25-82)
Sex (male:female)	14:5 (73.7%:26.3%)
Body mass index (kg/m2) (range)	22.3 ± 0.4 (21.5-23.5)
Hiatal hernia, n (%)	18 (94.7)
PPI medication, n (%)	19 (100)

PPI: Proton pump inhibitor.

Table 2 QUEST score, frequency scale for symptoms of the gastro-esophageal reflux disease score, and plication count after endoluminal gastroplication

	Baseline (n = 19)	3 mo (n = 19)	12 mo (n = 12)
QUEST score	5.7 ± 4.1	4.2 ± 4.5	2.5 ± 4.2
FSSG score	19.1 ± 10.5	10.3 ± 7.4a	9.3 ± 9.9a
Plication count	2.4 ± 0.8	1.2 ± 0.8a	0.8 ± 1.0a

^aP < 0.05 vs baseline by Kruskal Wallis test plus Steel-Dwass test. QUEST: Questionnaire for the diagnosis of reflux disease; FSSG: Frequency scale for symptoms of gastro-esophageal reflux disease.

Table 3 Twenty-four hour intra-esophageal ambulatory multichannel intraluminal impedance-pH monitoring data at baseline and 3 mo after endoluminal gastroplication

	n	Baseline	3 mo
24-h intra-esophageal time pH < 4 (%)	18	4.1 ± 4.0	10.4 ± 19.2
Numbers of reflux events, %	10	100.3 ± 16.1	79.5 ± 13.5
Symptom index (SI), %	10	70.9 ± 9.2	79.0 ± 10.1
Symptom sensitivity index (SSI), %	10	16.1 ± 12.9	3.9 ± 8.3b
Number of symptom events, %	10	27.2 ± 5.9	7.3 ± 5.2b

^bP < 0.01 vs 3 mo after endoluminal gastroplication by Wilcoxon’s signed rank test.

Table 4 Gastrointestinal symptoms rating scale and 36-item short-form at baseline and 3 mo after endoluminal gastroplication

	Baseline (n = 10)	3 mo (n = 10)
GSRS scale
Overall	2.5 ± 0.8	1.8 ± 0.4a
Acid reflux	3.3 ± 1.5	2.1 ± 0.7a
Abdominal pain	2.7 ± 1.4	1.8 ± 0.9a
Indigestion	2.6 ± 1.0	1.6 ± 0.8a
Diarrhea	1.8 ± 0.9	1.4 ± 0.6
Constipation	2.3 ± 1.3	1.9 ± 1.3
SF-36 scale
Physical functionin	46.6 ± 15.8	53.7 ± 3.8a
Role physical	36.9 ± 20.0	48.7 ± 15.7
Bodily pain	40.5 ± 16.7	52.7 ± 8.3
General health	43.2 ± 7.8	48.8 ± 6.2a
Vitality	42.9 ± 12.7	50.6 ± 6.7
Social functioning	44.0 ± 12.6	47.2 ± 9.9
Role emotional	37.2 ± 19.4	47.7 ± 13.7
Mental health	46.3 ± 11.8	43.3 ± 11.6

^aP < 0.05 vs 3 mo after endoluminal gastroplication by Wilcoxon’s signed rank test. GSRS: Gastrointestinal symptoms rating scale; SF-36: 36-item short-form.