Steroid-sparing strategies in the management of ulcerative colitis: Efficacy of leukocytapheresis

Table 1 Leukocytapheresis for steroid-naïve patients with active ulcerative colitis

Ref.	Patients (n)	Leukocytapheresis (sessions/wk)	Remission1 rate (%)
Hanai et al[14]	Steroid-naïve 8	Adacolumn	Naïve 88
	(steroid-refractory 31)	11/11	(refractory 81)
Suzuki et al[15]	20	Adacolumn	85
		5-10/2.5-5
Tanaka et al[25]	Steroid-naïve 26	Adacolumn	Naïve 85
	(steroid-dependent 19)	11 /12	(dependent 58)
Nishioka et al[26]	9	Cellsorba	33
		10 /10	(89 improved)
Umehara et al[27]	18	Cellsorba	61
		5 /5

¹Remission was defined as a clinical activity index (CAI) decrease to 4 or less and mucosal vascular patterns became at least partly visible in the studies by Hanai et al[14], Suzuki et al[24], and Nishioka et al[26], a CAI decrease to 4 or less in the study by Tanaka et al[25], and a CAI decrease to less than 4 in the study by Umehara et al[27].