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©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 28, 2012; 18(4): 368-374
Published online Jan 28, 2012. doi: 10.3748/wjg.v18.i4.368
Published online Jan 28, 2012. doi: 10.3748/wjg.v18.i4.368
Table 1 General status of gastric cancer patients and controls
| Variables | Patients (n = 332) (%) | Controls (n = 380) (%) | P value |
| Age (yr) | |||
| mean ± SE | 57.37 ± 0.68 | 56.92 ± 0.66 | 0.638 |
| Gender | |||
| Male | 208 (62.7) | 194 (51.1) | 0.002 |
| Female | 124 (37.3) | 185 (48.9) | |
| Helicobacter pylori infection | |||
| Yes | 138 (41.6) | 156 (41.1) | 0.89 |
| No | 194 (58.4) | 224 (58.9) | |
| Tobacco smoking | |||
| Yes | 86 (25.9) | 82 (21.6) | 0.175 |
| No | 246 (74.1) | 298 (78.4) | |
| Alcohol consumption | |||
| Yes | 63 (19.0) | 73 (19.2) | 0.937 |
| No | 269 (81.0) | 307 (80.8) |
Table 2 Genotype and allele distribution of ICAM-1 +469 A/G polymorphism
| Patients(n = 332) (%) | Controls(n = 380) (%) | P valuea | |
| Genotype | |||
| AA | 190 (57.2) | 187 (49.2) | 0.032b |
| AG | 116 (34.9) | 169 (42.4) | |
| GG | 26 (7.8) | 24 (8.4) | |
| Allele | |||
| A | 496 (74.7) | 543 (71.4) | 0.070 |
| G | 168 (25.3) | 217 (28.6) |
Table 3 Association between ICAM-1 +469 A/G polymorphism and clinicopathological parameters of patients with gastric cancer
| Variables | Total | ICAM-1 +469 A/G genotype | P value | |
| (n = 332) | AA(n = 190) (%) | AG + GG(n = 142) (%) | ||
| Age (yr) | 0.733 | |||
| mean ± SE | 57.17 ± 0.94 | 57.64 ± 0.99 | ||
| Gender | 0.355 | |||
| Male | 208 | 115 (60.5) | 93 (65.5) | |
| Female | 124 | 75 (39.5) | 49 (34.5) | |
| Tumor size | 0.154 | |||
| ≤ 5cm | 174 | 106 (55.8) | 68 (47.9) | |
| > 5cm | 158 | 84 (44.2) | 74 (52.1) | |
| Differentiation | 0.760 | |||
| Well | 120 | 70 (36.8) | 50 (35.2) | |
| Poor | 212 | 120 (63.2) | 92 (34.8) | |
| Lymph node metastasis | 0.928 | |||
| Negative | 102 | 58 (30.5) | 44 (31.0) | |
| Positive | 230 | 132 (69.5) | 98 (69.0) | |
| Vascular invasion | 0.408 | |||
| Negative | 176 | 97 (51.1) | 79 (55.6) | |
| Positive | 156 | 93 (48.9) | 63 (44.4) | |
| Distant metastasis | 0.002 | |||
| Negative | 286 | 154 (81.1) | 132 (93.0) | |
| Positive | 46 | 36 (18.9) | 10 (7.0) | |
| TNM stages | 0.046a | |||
| I | 62 | 35 (18.4) | 27 (19.0) | |
| II | 60 | 35 (18.4) | 25 (17.6) | |
| III | 134 | 68 (35.8) | 66 (46.5) | |
| IV | 76 | 52 (27.4) | 24 (16.9) | |
Table 4 ICAM-1 +469 A/G polymorphism and sICAM-1 and ICAM-1 expression in gastric cancer
| Characteristics | Total | Genotype | P value | |
| (n = 102) | AA | AG + GG | ||
| Serum sICAM-1 | 0.990 | |||
| mean ± SE | 176.00 ± 7.72 | 175.85 ± 9.40 | ||
| ICAM-1 expression | 0.197 | |||
| Positive | 29 | 13 (44.8) | 16 (55.2) | |
| Negative | 73 | 43 (58.9) | 30 (41.1) | |
- Citation: Tian MM, Sun Y, Li ZW, Wu Y, Zhao AL, Li JY. Polymorphisms of ICAM-1 are associated with gastric cancer risk and prognosis. World J Gastroenterol 2012; 18(4): 368-374
- URL: https://www.wjgnet.com/1007-9327/full/v18/i4/368.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i4.368