Nur-related receptor 1 gene polymorphisms and alcohol dependence in Mexican Americans

doi:10.3748/wjg.v18.i37.5276

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Oct 7, 2012 (publication date) through Jan 21, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2012; 18(37): 5276-5282
Published online Oct 7, 2012. doi: 10.3748/wjg.v18.i37.5276

Table 1 Genotype and allele frequency of the -2922(C)2-3 and -1198(C/G) allele in Mexican American alcoholics and nonalcoholics n (%)

Groups	-2922(C)2-3 allele					-1198(C/G) allele
	Genotype			Allele frequency	Total	Genotype			Allele frequency	Total
	*(C)2/(C)2*	*(C)2/(C)3*	*(C)3/(C)3*	*(C)3*		*C/C*	*C/G*	*G/G*	C
Non-alcoholic	119 (34.4)	132 (38.2)	95 (27.5)	322 (46.5)	346	76 (23.5)	146 (46.1)	98 (30.3)	298 (46.6)	320
Alcoholic	87 (23.3)	192 (51.3)	95 (25.4)^a	382 (51.1)	374	48 (13.9)	176 (50.9)	122 (35.3)^a	272 (39.3)^b	346

^aP = 0.007;

^bP = 0.005 vs nonalcoholic.

Table 2 Genotype and allele frequency of the -2922(C)2-3 allele in Mexican American alcoholics and non-alcoholics controlling for confounding effect of smokers and obesity n (%)

Groups	Genotype			Allele frequency
	(C)2/(C)2	(C)2/(C)3	(C)3/(C)3	(C)3
Non-alcoholic
BMI < 30 kg/m² (213)	73 (34.3)	78 (36.6)	62 (29.1)	202 (47.4)
BMI ≥ 30 kg/m² (122)	41 (33.6)	48 (39.3)	33 (27.0)	114 (46.7)
Alcoholic
BMI < 30 kg/m² (198)	37 (18.7)	107 (54.0)	54 (27.3)^a	215 (54.3)^b
BMI ≥ 30 kg/m² (146)	37 (21.5)	74 (50.7)	35 (25.9)	144 (49.3)
Non-alcoholic
Non-smokers (282)	100 (35.5)	101 (35.8)	81 (28.7)	263 (46.6)
Smokers (59)	17 (28.8)	29 (49.2)	13 (22.0)	55 (46.6)
Alcoholic
Non-smokers (197)	49 (24.9)	88 (44.7)	60 (30.5)^c	208 (52.8)
Smokers (177)	38 (21.5)	104 (58.8)	35 (19.8)^d	174 (49.2)

^aP = 0.000 vs nonalcoholic body mass index (BMI) < 30 kg/m²;

^bP = 0.049 vs nonalcoholic BMI < 30 kg/m²;

^cP = 0.037 vs non-alcoholic non-smokers;

^dP = 0.016 vs alcoholic non-smokers.

Table 3 Genotype and allele frequency of the -1198(C/G) allele in Mexican American alcoholics and non-alcoholics controlling for confounding effect of smoking and obesity n (%)

Groups	Genotype			Allele frequency
	C/C	C/G	G/G	C
Non-alcoholic
BMI < 30 kg/m² (199)	54 (27.1)	81 (40.7)	64 (32.2)	189 (47.5)
BMI ≥ 30 kg/m² (115)	21 (18.3)	62 (53.9)	32 (27.8)	104 (45.2)
Alcoholic
BMI < 30 kg/m² (181)	26 (14.4)	92 (50.8)	63 (34.8)^a	144 (39.8)^b
BMI ≥ 30 kg/m² (136)	18 (13.2)	73 (53.7)	45 (33.1)	109 (40.1)
Non-alcoholic
Non-smokers (265)	61 (23.0)	122 (46.0)	82 (30.9)	244 (46.0)
Smokers (55)	15 (18.3)	24 (53.9)	16 (27.8)	54 (49.1)
Alcoholic
Non-smokers (185)	27 (14.6)	90 (48.6)	68 (36.8)	144 (38.9)^c
Smokers (161)	21 (13.0)	86 (53.4)	54 (33.5)^d	128 (39.7)

^aP = 0.008 vs nonalcoholic body mass index (BMI) < 30 kg/m²;

^bP = 0.032 vs nonalcoholic BMI < 30 kg/m²;

^cP = 0.034 vs nonalcoholic non-smokers;

^dP = 0.05 vs non-alcoholic smokers.

Citation: Wei YM, Du YL, Nie YQ, Li YY, Wan YJY. Nur-related receptor 1 gene polymorphisms and alcohol dependence in Mexican Americans. World J Gastroenterol 2012; 18(37): 5276-5282
URL: https://www.wjgnet.com/1007-9327/full/v18/i37/5276.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i37.5276