High-definition colonoscopy with i-Scan: Better diagnosis for small polyps and flat adenomas

Table 1 Colonoscopies carried out for screening, diagnosis and surveillance n (%)

Indications	HD+ with i-Scan	Standard white light	Total
Screening	69 (23.9)	219 (76.1)	288
Diagnosis	156 (22.1)	552 (77.9)	708
Follow-up	27 (25.7)	78 (74.3)	105
Total	252	849	1101

HD: High-definition.

Table 2 High-definition+ with i-Scan and standard white-light colonoscopy detection rates of mucosal lesions

Indications	HD+ with i-Scan1	Standard white light1	P value
Screening	179/69 (2.59)	207/219 (0.94)	< 0.0001
Diagnosis	203/156 (1.3)	524/552 (0.94)	0.0105
Follow-up	77/27 (2.8)	76/78 (0.97)	< 0.0001
Total	459/252 (1.82)	807/849 (0.95)	< 0.0001

¹Number of lesion/procedure (mean). HD: High-definition.

Table 3 Number and size of protruding and nonprotruding lesions found with high-definition+ with i-Scan and standard white-light colonoscopy

	HD+ with i-Scan	Standard white light	Total	P value
0-10 mm				< 0.0001
Protruding	341	636	977
Nonprotruding	43	31	74
11-20 mm				0.83
Protruding	30	67	97
Nonprotruding	12	23	35
21-30 mm				0.36
Protruding	9	8	17
Nonprotruding	12	21	33
> 30 mm
Protruding	9	12	21	0.46
Nonprotruding	3	9	12

HD: High-definition.

Table 4 Histological report of nonprotruding lesions

	0-10 mm		11-20 mm		21-30 mm		> 30 mm		Total
	HD+with i-Scan	Standard white light	HD+with i-Scan	Standard white light	HD+with i-Scan	Standard white light	HD+with i-Scan	Standard white light
Missing	8	4	0	3	0	3	0	3	21
Hyperplastic	3	8	3	2	3	0	0	0	19
Serrated	29	16	6	18	9	18	0	0	96
LGIN	3	3	0	0	0	0	3	6	15
Adenocarcinoma	0	0	3	0	0	0	0	0	3
Total	43	31	12	23	12	21	3	9	154

HD: High-definition; LGIN: Low grade intraepithelial neoplasia.

Table 5 Procedures performed by the four endoscopists using the two techniques

Operator	Procedures	HD+ with i-Scan	Standard white light	Lesions	No. of lesions (mean number of lesions/procedure)		P value
					HD+ with i-Scan	Standard white light
1	264	57	207	330	117 (2.05)	213 (1.02)	< 0.0001
2	300	72	228	375	132 (1.83)	243 (1.07)	0.089
3	276	60	216	294	114 (1.9)	180 (0.83)	< 0.0001
4	261	63	198	267	96 (1.52)	171 (0.86)	0.71
Total	1101	252	849	1266	459 (1.82)	807 (0.95)	< 0.0001

HD: High-definition.