Health-related quality of life of 256 recipients after liver transplantation

doi:10.3748/wjg.v18.i36.5114

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 18, Issue 36

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3463)

All Articles published online

The chart showing PDF series, HTML series, Tables (1-5) series.

Item

Count

PDF

412

HTML

2805

Tables (1-5)

231

Sum=3448

Sep 28, 2012 (publication date) through Dec 26, 2024

Times Cited of This Article

Times Cited (31)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Brief Article

World J Gastroenterol. Sep 28, 2012; 18(36): 5114-5121
Published online Sep 28, 2012. doi: 10.3748/wjg.v18.i36.5114

Table 1 Recipient characteristics

Factors	n (%)
Age, yr (mean ± SD, 44.57 ± 9.97)
≤ 45	151 (59)
> 45	105 (41)
Sex
Male	211 (82.4)
Female	45 (17.6)
Marital status
Married	241 (94.1)
Unmarried	3 (1.2)
Divorced/widowed	12 (4.7)
Education attainment
Elementary school	15 (5.9)
Middle school	108 (42.2)
University	133 (52)
Household income (RMB/mo)
≤ 1000	35 (13.7)
> 1000 to ≤ 3000	153 (59.8)
> 3000	68 (26.6)
Etiology disease
Hepatic cirrhosis	142 (55.5)
HCC	71 (27.7)
Severe hepatitis	30 (11.7)
Others	13 (5.1)
HCC/non-HCC	71 (27.7)/185 (72.3)
Complications (yes/no)	78 (30.5)/178 (69.5)
LT types (DDLT/LDLT)	190 (74.2)/66 (25.8)
Time since transplant
≤ 1 yr	38 (14.8)
> 1 yr, ≤ 3 yr	54 (21.1)
> 3 yr, ≤ 5 yr	66 (25.8)
> 5 yr	98 (38.3)
Employment after transplant
Full-time	83 (32.4)
Part-time	75 (29.3)
None	98 (38.3)

HCC: Hepatocellular carcinoma; DDLT: Deceased donor liver transplantation; LDLT: Living donor liver transplantation.

Table 2 Psychological outcomes after transplantation

BAI/SDS scores	Frequency	mean ± SD (%)
BAI		30.26 ± 7.44
< 45	241	94.1
≥ 45	15	5.9
SDS		0.49 ± 0.11
< 0.5	114	44.5
≥ 0.5, ≤ 0.59	104	40.6
≥ 0.6, ≤ 0.69	34	13.3
≥ 0.7	4	1.6

BAI: Beck anxiety inventory; SDS: Self-rating depression scale.

Table 3 Recipient health-related quality of life

Factors SF-36 domains	Groups (mean ± SD)	Groups (mean ± SD)	Groups (mean ± SD)	t/F value	P value
LT types	DDLT	LDLT
GH	66.86 ± 18.42	60.33 ± 16.97		t = 2.530	0.012
RP	74.47 ± 36.46	63.64 ± 42.55		t = 1.990	0.048
RE	78.95 ± 34.31	61.11 ± 44.37		t = 3.361	< 0.001
SF	88.16 ± 21.85	78.60 ± 22.76		t = 3.029	0.003
VT	75.95 ± 16.40	70.30 ± 15.76		t = 2.433	0.016
MH	71.85 ± 15.45	65.88 ± 12.94		t = 2.816	0.005
PCS	62.58 ± 6.88	60.07 ± 7.36		t = 2.507	0.013
MCS	55.95 ± 10.14	52.65 ± 7.66		t = 2.415	0.016
Age	≤ 45 yr	> 45 yr
VT	72.52 ± 16.66	77.33 ± 15.64		t = -2.332	0.020
MH	68.00 ± 14.65	73.64 ± 15.06		t = -2.995	0.003
MCS	54.05 ± 9.30	56.61 ± 10.00		t = -2.097	0.037
Complications	Yes	No
MCS	52.92 ± 12.21	56.06 ± 8.16		t = 2.412	0.017
Employment after transplant	Full-time	Part-time	None
GH	69.31 ± 18.23	63.88 ± 18.51	62.67 ± 17.63^a	F = 3.301	0.038
PF	88.67 ± 10.91	81.33 ± 17.66^a	83.32 ± 13.64^a	F = 5.809	0.003
SF	90.81 ± 20.01	85.67 ± 22.95	81.38 ± 23.28^a	F = 4.069	0.018
BP	86.02 ± 13.38	78.91 ± 19.76^a	78.76 ± 16.19^a	F = 5.331	0.005
VT	78.25 ± 15.86	72.93 ± 17.63	72.50 ± 15.45^a	F = 3.305	0.038
PCS	64.28 ± 6.20	60.87 ± 7.51^a	61.93 ± 7.08^a	F = 7.100	< 0.001

Only statistically significant data are displayed.

^aP = 0.05 vs group ”Full-time”. SF-36: Short Form-36; GH: General health; RP: Role-physical; RE: Role-emotional; SF: Social-functioning; VT: Vitality; MH: Mental health; PF: Physical functioning; BP: Bodily pain; LT: Liver transplantation; PCS: Physical component summary; MCS: Mental component summary.

Table 4 Health-related quality of life in liver recipients

SF-36 domain	LT (n = 256)	Sichuan general (n = 2249)	CHB (n = 150)	Healthy control (n = 126)	DM2 (n = 108)
General health	65.18 ± 18.25	67.30 ± 21.97	50.2 ± 24.0^a	91.23 ± 11.02^a	62.95 ± 23.87
Physical-functioning	84.47 ± 14.44	90.80 ± 15.07^a	84.5 ± 15.6	76.36 ± 26.09^a	87.38 ± 17.10^a
Role-physical	71.68 ± 38.33	79.51 ± 34.70^a	73.4 ± 27.4	82.79 ± 20.01^a	62.73 ± 39.64^a
Role-emotional	74.35 ± 37.89	76.45 ± 38.47	77.6 ± 23.8	69.46 ± 16.89	58.33 ± 43.74^a
Social-functioning	85.69 ± 22.43	85.29 ± 18.06	78.6 ± 25.8^a	74.44 ± 17.32^a	77.78 ± 25.60^a
Bodily pain	81.35 ± 16.17	82.41 ± 21.25	71.3 ± 26.0^a	85.55 ± 18.02^a	78.75 ± 25.48^a
Vitality	74.39 ± 16.41	71.44 ± 15.81^a	60.8 ± 23.6^a	75.57 ± 25.71	66.16 ± 21.66^a
Mental health	70.36 ± 15.05	73.52 ± 15.68^a	72.0 ± 20.3	73.35 ± 21.26^a	73.74 ± 21.08^a
PCS	61.93 ± 7.08	50.00 ± 10.00^a	42.8 ± 11.6^a	-	-
MCS	55.10 ± 9.66	50.00 ± 10.00^a	48.9 ± 12.3^a	-	-

Health-related quality of life (HRQoL) in liver recipients respectively compared with Sichuan general population and patients with chronic hepatitis B (CHB) or type 2 diabetes mellitus (DM2) as well as 126 healthy controls.

^aP< 0.05 vs group ”Liver transplantation (LT)”. SF-36: Short Form-36; PCS: Physical component summary; MCS: Mental component summary.

Table 5 Correlation analysis between health-related quality of life and psychological outcomes

BAI/SDS scores	PCS (SF-36)		MCS (SF-36)
BAI/SDS scores	r	P value	r	P value
BAI	-0.397	0.001	-0.401	< 0.001
SDS	-0.271	0.001	-0.239	< 0.001

BAI: Beck anxiety inventory; SDS: Self-rating depression scale; SF-36: Short Form-36; PCS: Physical component summary; MCS: Mental component summary.

Citation: Chen PX, Yan LN, Wang WT. Health-related quality of life of 256 recipients after liver transplantation. World J Gastroenterol 2012; 18(36): 5114-5121
URL: https://www.wjgnet.com/1007-9327/full/v18/i36/5114.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i36.5114