Novel insight into mechanisms of cholestatic liver injury

doi:10.3748/wjg.v18.i36.4985

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Sep 28, 2012 (publication date) through Dec 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2012; 18(36): 4985-4993
Published online Sep 28, 2012. doi: 10.3748/wjg.v18.i36.4985

Table 1 Human plasma bile acid concentrations in healthy volunteers and patients with extrahepatic cholestasis

BA	Healthy volunteers (nmol/L)	Cholestatic patients (nmol/L)
CDCA	257 ± 56	84 ± 60
TCDCA	120 ± 22	16 578 ± 4370
GCDCA	776 ± 112	28 535 ± 5734
CA	182 ± 83	173 ± 137
TCA	180 ± 47	54 487 ± 13 419
GCA	233 ± 56	56 222 ± 15 714
UDCA	138 ± 25	20 ± 11
TUDCA	5 ± 1	75 ± 22
LCA	13 ± 2	2 ± 1
TLCA	23 ± 4	12 ± 2
GLCA	16 ± 4	11 ± 2
LCA-S	7 ± 1	4 ± 2
DCA	387 ± 66	21 ± 16
TDCA	45 ± 12	213 ± 71
GDCA	246 ± 43	418 ± 91

BA: Bile acid; CA: Cholic acid; CDCA: Chenodeoxycholic acid; DCA: Deoxycholic acid; GCA: Glycocholic acid; GCDCA: Glycochenodeoxycholic acid; GDCA: Glycodeoxycholic acid; LCA: Lithocholic acid; TCA: Taurocholic acid; TCDCA: Taurochenodeoxycholic acid; TLCA: Taurolithocholic acid; TUDCA: Tauroursodeoxycholic acid; UDCA: Ursodeoxycholic acid; LCA-S: Lithocholic acid sulfate; GLCA: Glycolithocholic acid; TDCA: Taurodeoxycholic acid. Data adapted from Trottier et al[9].

Table 2 Murine plasma bile acid concentrations after bile duct ligation

BA	Sham control (μmol/L)	BDL 6 h (μmol/L)
TMCA	0.229 ± 0.029	1.003 ± 133
TCA	0.122 ± 0.027	1.072 ± 137
TCDCA	0.029 ± 0.003	7 ± 0.557
GCA	0.007 ± 0.0002	1 ± 0.118
GCDCA	0.003 ± 0.003	0 ± 0
αMCA	0.697 ± 0.273	87 ± 41
βMCA	0.175 ± 0.23	253 ± 100
CA	0.219 ± 0.059	17 ± 10
CDCA	0.0001 ± 0.0001	0.144 ± 0.085
TUDCA	0.031 ± 0.002	16 ± 14
TDCA	0.016 ± 0.004	0.330 ± 0.107
TLCA	0.007 ± 0.002	0.027 ± 0.002
UDCA	0.131 ± 0.002	0.492 ± 0.215
DCA	0.042 ± 0.018	0.109 ± 0.032
LCA	0.054 ± 0.013	0.033 ± 0.022

Citation: Woolbright BL, Jaeschke H. Novel insight into mechanisms of cholestatic liver injury. World J Gastroenterol 2012; 18(36): 4985-4993
URL: https://www.wjgnet.com/1007-9327/full/v18/i36/4985.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i36.4985