Brief Article
Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 21, 2012; 18(35): 4944-4958
Published online Sep 21, 2012. doi: 10.3748/wjg.v18.i35.4944
Table 1 Characteristics of selected trials
Ref.InterventionnMale (%)Age (range)Metastatic (%)Response rate (%)Median PFS (mo)1-yr OSMedian OS (mo)Quality
Louvet et al[15]Gem1635360.1 (22-75)7017.33.727.87.14
Gem + Oxaliplatin1636061.3 (35-77)6826.85.834.79.0
Poplin et al[16]Gem27556.464 (31-88)90.262.6164.94
Gem + Oxaliplatin27245.663 (29-96)89.392.7215.7
Heinemann et al[17]Gem9561.966 (43-85)78.99.03.124.76.04
Gem + Cisplatin9565.364 (37-82)8011.55.325.37.5
Colucci et al[18]Gem545063 (43-75)659.221154
Gem + Cisplatin533560 (33-71)6826.4511.37.5
Colucci et al[19]Gem19956.863 (37-75)82.910.13.934.08.34
Gem + Cisplatin20162.263 (35-75)84.611.43.830.77.2
Kulke et al[20]Gem646658.9 (31-81)143.3NR6.44
Gem + Cisplatin665658.9 (36-84)100134.5NR6.7
Gem + Irinotecan646860.8 (32-77)144.0NR7.1
Berlin et al[21]Gem16253.764.3 (33-85)90.15.62.2NR5.44
Gem + 5-fluorouracil16051.865.8 (28-84)89.46.93.4NR6.7
Herrmann et al[22,24]Gem1595362 (36-84)7983.9307.24
Gem + Capecitabine1605462 (27-83)80104.3328.4
Cunningham et al[23]Gem2665862 (26-83)7112.43.822.06.24
Gem + Capeitabine2676062 (37-82)7019.15.324.37.1
Scheithauer et al[25]Gem425566 (39-75)100144.037.28.24
Gem + Capeitabine416664 (40-75)100175.131.89.5
Costanzo et al[26]Gem494864 (34-75)7383.5187.754
Gem + 5-fluorouracil456362 (44-75)67114.5207.5
Abou-Alfa et al[27]Gem1745762.3 (30-84)785.73.8216.24
Gem + Exatecan1755363.0 (36-85)797.13.7236.7
Stathopoulos et al[28]Gem744264 (44-83)66102.921.86.54
Gem + Irinotecan713964 (31-84)60152.824.36.4
Lima et al[29]Gem18053.360.2 (32-82)80.64.43.0226.64
Gem + Irinotecan18057.263.2 (38-81)82.216.13.5216.3
Moore et al[38]Gem2845764 (36.1-92)75.08.0   3.55175.914
Gem + Erlotinib28547.763.7 (37-84)76.58.6  3.75236.24
Cutsem et al[39]Gem3475862 (30-88)7783.6246.064
Gem + Tipifarnib3415761 (29-89)7663.7276.43
Eckhardt et al[40]Gem1205960 (35-86)73NR3.03NR7.365
Gem + Tipifarnib1246463 (35-81)71NR2.3NR6.73
Philip et al[37]Gem3715464.37873.0NR5.94
Gem + cetuximab3725163.77983.4NR6.3
Kindler et al[36]Gem3005165.0 (35-86)85102.9NR5.94
Gem + Bevacizumab3025863.7 (26-88)84133.8NR5.8
Kindler et al[35]Gem3165962 (35-89)721.64.4NR8.35
Gem + Axitinib3166161 (34-84)724.94.4NR8.5
Spano et al[41]Gem344761.0 (36-78)1933.723.55.64
Gem + Axitinib695165.0 (44-81)4074.236.86.9
Friess et al[34]Gem434266 (56-80)91143.830.247.74
Gem + Cilengitide465768 (40-80)94173.660.156.7
Richards et al[33]Gem4472.764.1 (41-83)86.45.33.0175.14
Gem + Enzastarin8653.568.3 (39-86)90.78.63.4195.6
Bramhall et al[31]Gem1197162 (37-85)62163.2175.465
Gem + Marimastat1206962 (32-83)59113.08185.51
Richards et al[32]Gem8560.265 (36-83)83.013.93.43NR7.135
Gem + CA-9948559.362 (32-82)82.611.83.06NR6.47
Oettle et al[30]Gem28253.563 (28-82)91.17.13.320.16.34
Gem + PPemetrexed28360.463 (27-82)90.114.83.921.46.2
Table 2 Grade 3 or 4 toxicity of selected clinical trials
Ref.InterventionVomitingDiarrheaNeutropeniaAnemiaThrombocytopenia
Louvet et al[15]Gem3.21.327.610.33.2
Gem + Oxaliplatin8.95.720.46.414.0
Poplin et al[16]Gem74331013
Gem + Oxaliplatin16622611
Heinemann et al[17]Gem5.94.7NR10.610.6
Gem + Cisplatin22.23.3NR13.34.4
Colucci et al[18]Gem20942
Gem + Cisplatin241862
Colucci et al[19]Gem< 11.513.7118.9
Gem + Cisplatin2.6< 124.74.815.3
Kulke et al[20]Gem24.1NR82.82043.1
Gem + Cisplatin29NR74.225.879
Gem + Irinotecan16.7NR41.78.323.3
Berlin et al[21]Gem8NR51011
Gem + 5-fluorouracil7NR71019
Herrmann et al[22,24]Gem421968
Gem + Capeitabine452384
Cunningham et al[23]Gem642266
Gem + Capeitabine6535411
Scheithauer et al[25]Gem007.602.5
Gem + Capeitabine051050
Costanzo et al[26]Gem00260
Gem + 5-fluorouracil20272
Abou-Alfa et al[27]Gem3.1< 114.67.64.4
Gem + Exatecan5.31.130.35.915.4
Stathopoulos et al[28]Gem1.42.815.74.20
Gem + Irinotecan1.63.226.655
Lima et al[29]Gem8.21.831.91314.2
Gem + Irinotecan13.918.537.616.219.6
Moore et al[38]GemNR< 127%NR11%
Gem + ErlotinibNR224%NR10%
Cutsem et al[39]Gem93301612
Gem + Tipifarnib74402015
Eckhardt et al[40]Gem9.3033.91115.3
Gem + Tipifarnib4035.512.116.1
Philip et al[37]Gem2.22.523.96.28.5
Gem + cetuximab6.62.823.39.76.6
Kindler et al[36]GemNRNR29812
Gem + BevacizumabNRNR33512
Kindler et al[35]Gem3.21.6< 1< 1< 1
Gem + Axitinib3.91.3000
Spano et al[41]Gem100331713
Gem + Axitinib6628820
Richards et al[33]Gem02.628.25.125.6
Gem + Enzastarin2.43.718.33.714.6
Bramhall et al[31]Gem14%NRNR7%NR
Gem + Marimastat6%NRNR3%NR
Richards et al[32]Gem93NR511
Gem + CA-99495NR132
Oettle et al[30]Gem3.70.712.82.96.2
Gem + Pemetrexed3.32.945.113.917.9