Copyright
©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 14, 2012; 18(34): 4758-4764
Published online Sep 14, 2012. doi: 10.3748/wjg.v18.i34.4758
Published online Sep 14, 2012. doi: 10.3748/wjg.v18.i34.4758
Table 1 Clinical characteristics of the study subjects
Items | Han population | Uyghur population | Total |
UC patients | 53 | 49 | 102 |
Gender (male/female) | 22/31 | 25/24 | 47/55 |
Age of onset (yr) | 52 ± 15 | 46 ± 15 | 48 ± 16 |
Extensive colitis | 20 (0.38) | 30 (0.61) | 50 (0.49) |
Distal colitis | 33 (0.62) | 19 (0.39) | 52 (0.51) |
Mild and moderate | 47 (0.89) | 40 (0.82) | 87 (0.85) |
Severe | 6 (0.11) | 9 (0.18) | 15 (0.15) |
Healthy controls | 161 | 149 | 310 |
Gender (male/female) | 67/94 | 70/79 | 137/173 |
Age of onset (yr) | 48 ± 15 | 49 ± 13 | 47 ± 14 |
Table 2 Genotypic association of four single nucleotide polymorphisms with ulcerative colitis in Han and Uyghur populations n (%)
SNPs | Allele | Groups | UC cases | Controls | χ2 | P |
rs281377 | C/T | Han | 0 (0)/6 (11.3)/47 (88.7) | 9 (5.6)/42 (26.1)/110 (68.4) | 9.091 | 0.011 |
C/T | Uyghur | 10 (20.4)/12 (24.5)/27 (55.1) | 15 (10.1)/59 (39.6)/75 (50.3) | 5.633 | 0.060 | |
rs1047781 | T/A | Han | 5 (9.5)/13 (24.5)/35 (66.0) | 19 (11.8)/61 (37.9)/81 (50.3) | 4.077 | 0.130 |
T/A | Uyghur | 2 (4.0)/4 (8.2)/43 (87.8) | 10 (6.7)/50 (33.6)/89 (59.7) | 13.480 | 0.001 | |
rs601338 | A/G | Han | 0 (0)/1 (1.9)/52 (98.1) | 3 (1.8)/23 (14.3)/135 (83.9) | 7.382 | 0.025 |
A/G | Uyghur | 6 (12.2)/9 (18.4)/34 (69.4) | 20 (13.4)/76 (51.0)/53 (35.6) | 18.790 | 8.33 × 10-5 | |
rs602662 | A/G | Han | 0 (0)/3 (5.7)/50 (94.3) | 0 (0)/9 (5.6)/152 (94.4) | NA | NA |
A/G | Uyghur | 5 (10.2)/15 (30.6)/29 (59.2) | 11 (7.4)/61 (40.9)/77 (51.7) | 1.776 | 0.412 |
Table 3 Allelic association of four single nucleotide polymorphisms with ulcerative colitis in Han, Uyghur and combined populations
SNPs | Groups | Risk allele | Frequency (case/control) | χ2 | Pobs | Pemp | OR (95% CI) | P (Q) | Poverall | OR (95% CI) |
rs281377 | Han | C | 0.057/0.186 | 10.290 | 0.001 | 0.002 | 0.26 (0.11-0.63) | 0.003 | 0.100 | 0.71 (0.47-1.07) |
Uyghur | C | 0.327/0.299 | 0.270 | 0.603 | 0.636 | 1.14 (0.70-1.86) | ||||
rs1047781 | Han | T | 0.217/0.308 | 3.203 | 0.074 | 0.106 | 0.62 (0.37-1.05) | 0.100 | 0.005 | 0.47 (0.31-0.72) |
Uyghur | T | 0.082/0.235 | 10.950 | 0.001 | 0.002 | 0.29 (0.13-0.63) | ||||
rs601338 | Han | A | 0.009/0.090 | 7.954 | 0.005 | 0.102 | 0.10 (0.01-0.72) | 0.140 | 0.0003 | 0.35 (0.21-0.58) |
Uyghur | A | 0.214/0.389 | 9.979 | 0.002 | 0.002 | 0.43 (0.25-0.73) | ||||
rs602662 | Han | A | 0.028/0.028 | 0.000 | 0.985 | 1.000 | 1.01 (0.27-3.81) | 0.860 | 0.680 | 0.90 (0.56-1.47) |
Uyghur | A | 0.255/0.279 | 0.204 | 0.652 | 0.699 | 0.89 (0.53-1.49) |
- Citation: Aheman A, Luo HS, Gao F. Association of fucosyltransferase 2 gene variants with ulcerative colitis in Han and Uyghur patients in China. World J Gastroenterol 2012; 18(34): 4758-4764
- URL: https://www.wjgnet.com/1007-9327/full/v18/i34/4758.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i34.4758