7-difluoromethoxyl-5,4&rsquo;-di-n-octylgenistein inhibits growth of gastric cancer cells through downregulating forkhead box M1

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Sep 7, 2012 (publication date) through Dec 2, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2012; 18(33): 4618-4626
Published online Sep 7, 2012. doi: 10.3748/wjg.v18.i33.4618

Table 1 Structures of genistein and its difluoromethylated derivatives

Compound		R1	R2
1	Genistein (5,7,4’-trihydroxylisoflavone)	H	H
2	7-difluoromethyl genistein	CHF₂	H
4a	7-difluoromethyl-5,4’-dimethyl genistein	CHF₂	CH₃
4b	7-difluoromethyl-5,4’-diethyl genistein	CHF₂	CH₃CH₂
4c	7-difluoromethyl-5,4’-di-n-propyl genistein	CHF₂	n-C₃H₇
4d	7-difluoromethyl-5,4’-di-benzyl genistein	CHF₂	C₆H₅CH₂
4e	7-difluoromethyl-5,4’-diheptyl genistein	CHF₂	n-C₇H₁₅
4f	7-difluoromethyl-5,4’-di-n-octyl genistein	CHF₂	n-C₈H₁₇
4g	7-difluoromethyl-5,4’-didecyl genistein	CHF₂	n-C₁₀H₂₁
4h	7-difluoromethyl-5,4’-diisobutyl genistein	CHF₂	iso-C₄H₉

Citation: Xiang HL, Liu F, Quan MF, Cao JG, Lv Y. 7-difluoromethoxyl-5,4’-di-n-octylgenistein inhibits growth of gastric cancer cells through downregulating forkhead box M1. World J Gastroenterol 2012; 18(33): 4618-4626
URL: https://www.wjgnet.com/1007-9327/full/v18/i33/4618.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i33.4618