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©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 7, 2012; 18(33): 4549-4556
Published online Sep 7, 2012. doi: 10.3748/wjg.v18.i33.4549
Published online Sep 7, 2012. doi: 10.3748/wjg.v18.i33.4549
Clinical characteristics | Short course RT | Long course RT | Control | P1 |
Study population (n = 214) | ||||
Male | 57 (63) | 34 (64) | 32 (45) | 0.03 |
Female | 33 (37) | 19 (36) | 39 (55) | |
Mean age (yr) | 65.2 | 64.7 | 74.5 | < 0.001 |
Preoperative T | ||||
T1-2 | 28 (31) | 0 (0) | 22 (31) | |
T3 | 54 (60) | 2 (4) | 12 (17) | < 0.001 |
2T4 | 1 (1) | 50 (94) | 3 (4) | |
Tx | 7 (8) | 1 (2) | 34 (48) | |
Postoperative T | ||||
T1 | 3 (3) | 2 (4) | 5 (7) | |
T2 | 34 (38) | 6 (11) | 26 (37) | |
T3 | 50 (56) | 27 (51) | 37 (52) | < 0.001 |
T4 | 3 (3) | 14 (26) | 3 (4) | |
T0 | 0 | 4 (8) | 0 | |
Postoperative N | ||||
N0 | 53 (59) | 36 (68) | 41 (58) | |
N1 | 26 (29) | 14 (26) | 15 (21) | 0.33 |
N2 | 11 (12) | 3 (6) | 12 (17) | |
Nx | 0 | 0 | 3 (4) | |
Grade | ||||
G1 | 9 (10) | 10 (19) | 12 (17) | |
G2 | 58 (64) | 33 (62) | 48 (68) | 0.07 |
G3 | 21 (23) | 3 (6) | 11 (16) | |
Gx | 2 (2) | 7 (13) | 0 | |
3Crm (mm) | ||||
0 | 3 (4) | 11 (25) | 4 (9) | |
0 ≤ crm ≤ 2 | 9 (12) | 7 (16) | 7 (16) | 0.009 |
> 2 | 65 (84) | 26 (59) | 32 (74) | |
Disease specific outcome | ||||
Alive without recurrence | 64 (71) | 25 (47) | 39 (55) | |
Alive with recurrence | 7 (8) | 7 (13) | 4 (6) | 0.07 |
Died of disease | 11 (12) | 12 (23) | 18 (25) | |
Died of other causes | 8 (9) | 9 (17) | 10 (14) |
Variable (n = 177) | "Front-positive"(n = 105) | "Front-negative"(n = 72) | P1 |
Treatment group | |||
Short-course RT | 46 (44) | 32 (44) | |
Long-course RT | 24 (23) | 14 (19) | 0.87 |
Control | 35 (33) | 26 (36) | |
Postoperative T | |||
T1-2 | 43 (41) | 21 (29) | |
T3 | 55 (52) | 42 (58) | 0.19 |
T4 | 7 (7) | 9 (13) | |
Postoperative N | |||
N0 | 68 (65) | 40 (56) | |
N1-2 | 36 (34) | 31 (43) | 0.37 |
Nx | 1 (1) | 1 (1) | |
2Crm | |||
≤ 2 mm | 14 (18) | 22 (38) | 0.01 |
> 2 mm | 64 (82) | 36 (62) | |
Tumor growth pattern | |||
Expanding | 63 (60) | 23 (32) | < 0.001 |
Infiltrating | 42 (40) | 49 (68) | |
Disease-specific outcome | |||
Alive without recurrence | 68 (65) | 39 (54) | |
Alive with recurrence | 3 (3) | 12 (17) | 0.01 |
Died of disease | 21 (20) | 15 (21) | |
Died of other causes | 13 (12) | 6 (8) |
Variable | DFS | DSS | ||||
Adjusted HR | 95% CI | P | Adjusted HR | 95% CI | P | |
Sex | ||||||
Female (ref) | 1.0 | 1.0 | ||||
Male | 1.9 | 1.0-3.5 | 0.04 | 1.5 | 0.7-3.0 | 0.3 |
Age | ||||||
< 70 yr (ref) | 1.0 | 1.0 | ||||
≥ 70 yr | 1.4 | 0.8-2.4 | 0.3 | 4.7 | 2.1-10.5 | < 0.001 |
Postoperative T | ||||||
T1-2 (ref) | 1.0 | 1.0 | ||||
T3 | 3.2 | 1.4-7.2 | 0.005 | 2.0 | 0.8-5.1 | 0.1 |
T4 | 5.9 | 2.0-17.0 | 0.001 | 4.8 | 1.4-17.0 | 0.02 |
Postoperative N | ||||||
N0 (ref) | 1.0 | 1.0 | ||||
N1-2, Nx | 2.0 | 1.1-3.7 | 0.02 | 0.8 | 0.4-1.7 | 0.6 |
1Postoperative grade | ||||||
G1 (ref) | 1.0 | |||||
G2 | 1.3 | 0.4-3.9 | 0.7 | |||
G3 | 5.2 | 1.6-17.4 | 0.007 | |||
Growth pattern | ||||||
Expanding (ref) | 1.0 | 1.0 | ||||
Infiltrating | 1.0 | 0.5-1.8 | 0.9 | 0.8 | 0.4-1.7 | 0.6 |
1CD44v6 staining pattern | ||||||
“Front-positive” (ref) | 1.0 | |||||
“Front-negative” | 1.4 | 0.8-2.6 | 0.2 | |||
Recurrence | ||||||
No (ref) | 1.0 | |||||
Yes | 74.3 | 17.0-326.7 | < 0.001 |
- Citation: Avoranta ST, Korkeila EA, Syrjänen KJ, Pyrhönen SO, Sundström JTT. Lack of CD44 variant 6 expression in rectal cancer invasive front associates with early recurrence. World J Gastroenterol 2012; 18(33): 4549-4556
- URL: https://www.wjgnet.com/1007-9327/full/v18/i33/4549.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i33.4549