Tissue transglutaminase levels above 100 U/mL and celiac disease: A prospective study

doi:10.3748/wjg.v18.i32.4399

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Aug 28, 2012 (publication date) through Dec 20, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2012; 18(32): 4399-4403
Published online Aug 28, 2012. doi: 10.3748/wjg.v18.i32.4399

Table 1 Results of small-intestinal biopsy and serology n (%)

		Biopsy data
		Patients n = 183 (100.0)	Patients with CD n = 120 (65.6)	Patients with normal histology n = 63 (34.4)
IgA EMA	Negative	47 (25.7)	4 (3.3)	43 (68.3)
	Positive	136 (74.3)	116 (96.7)	20 (31.7)
IgA tTGA > 10	Negative	53 (29.0)	4 (3.3)	49 (77.8)
	Positive	130 (71.0)	116 (96.7)	14 (22.2)
IgA tTGA ≥ 100	Negative	96 (52.5)	33 (27.5)	63 (100)
	Positive	87 (47.5)	87 (72.5)	0 (0.0)

CD: Celiac disease; IgA: Immunoglobulin A; EMA: Anti-endomysium antibodies; tTGA: Anti-tissue-transglutaminase antibodies.

Table 2 Sensitivity, specificity, positive predictive value and negative predictive value of anti-endomysium antibodies and anti-tissue-transglutaminase antibodies (%)

	Sensitivity	Specificity	PPV	NPV
IgA EMA	97 (91-99)	68 (55-79)	85 (78-90)	91 (79-97)
IgA tTGA >10	97 (91-99)	78 (65-87)	89 (82-94)	92 (81-98)
IgA tTGA ≥ 100	73 (63-80)	100 (93-100)	100 (95-100)	66 (55-75)

The 95% CI are given in parentheses. IgA: Immunoglobulin A; EMA: Anti-endomysium antibodies; tTGA: Anti-tissue-transglutaminase antibodies; PPV: Positive predictive value; NPV: Negative predictive value.

Citation: Mubarak A, Wolters VM, Gmelig-Meyling FH, ten Kate FJ, Houwen RH. Tissue transglutaminase levels above 100 U/mL and celiac disease: A prospective study. World J Gastroenterol 2012; 18(32): 4399-4403
URL: https://www.wjgnet.com/1007-9327/full/v18/i32/4399.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i32.4399