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©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Aug 7, 2012; 18(29): 3883-3888
Published online Aug 7, 2012. doi: 10.3748/wjg.v18.i29.3883
Published online Aug 7, 2012. doi: 10.3748/wjg.v18.i29.3883
Table 1 Histological criteria for International Consensus Diagnostic Criteria
Level 1 | Level 2 | |
Type 1 AIP | ||
Histology of the pancreas | LPSP (core biopsy/resection) | LPSP (core biopsy) |
At least 3 of the following: | Any 2 of the following: | |
(1) Periductal lymphoplasmacytic infiltrate without granulocytic infiltration | (1) Periductal lymphoplasmacytic infiltrate without granulocytic infiltration | |
(2) Obliterative phlebitis | (2) Obliterative phlebitis | |
(3) Storiform fibrosis | (3) Storiform fibrosis | |
(4) Abundant (> 10 cells/HPF) IgG4-positive cells | (4) Abundant (> 10 cells/HPF) IgG4-positive cells | |
Type 2 AIP | ||
Histology of the pancreas (core biopsy/resection) | IDCP | |
Both of the following: | Both of the following: | |
(1) GEL with or without granulocytic acinar inflammation (2) Absent or scant (0-10 cells/HPF) IgG4-positive cells | (1) Granulocytic and lymphoplasmacytic acinar infiltrate (2) Absent or scant (0-10 cells/HPF) IgG4-positive cells |
Table 2 Results of endoscopic ultrasound-guided fine needle aspiration specimen n (%)
Pancreatic head (n = 21) | Pancreatic body-tail (n = 26) | Total (n = 47) | P value | |
Average number of FNA passes | 2.00 ± 0.43 | 2.04 ± 0.514 | 2.02 ± 0.48 | 0.78 |
(1-3) | (1-4) | (1-4) | ||
Adequate sample material | 17 (80.9) | 26 (100) | 43 (91.4) | 0.07 |
Lymphoplasmacytic infiltration | 6 (28.6) | 10 (38.4) | 16 (34.0) | 0.68 |
Storiform fibrosis | 12 (57.1) | 22 (84.6) | 34 (72.3) | 0.07 |
Obliterative phlebitis | 0 (0) | 0 (0) | 0 (0) | 1 |
Abundant IgG4-positive plasmacyte infiltration | 3/10 (30) | 7/18 (38.8) | 10/28 (35.7) | 1 |
Granulocytic infiltration of duct wall | 0 (0) | 0 (0) | 0 (0) | 1 |
Granulocytic acinar infiltrate | 1 (4) | 2 (7.7) | 3 (6.3) | 1 |
Complications | 0 (0) | 0 (0) | 0 (0) | 1 |
Table 3 Patients with level 2 histological findings of lymphoplasmacytic sclerosing pancreatitis
Case | Sex | Age, yr | IgG4 (mg/dL) | Location | Response to steroid | OOI | Diagnosis |
1 | Male | 74 | 263 | Diffuse | (+) | Nephritis | Definitive type 1 AIP |
2 | Female | 71 | 364 | Diffuse | (+) | Cholangitis | Definitive type 1 AIP |
3 | Male | 54 | 230 | Focal | (+) | Sialadenitis | Definitive type 1 AIP |
4 | Male | 47 | 104 | Focal | (+) | None | Definitive type 1 AIP |
5 | Male | 57 | 46 | Focal | (+) | None | Definitive type 1 AIP |
Table 4 Patients with level 2 histological findings of idiopathic duct-centric pancreatitis
Case | Sex | Age, yr | IgG4 (mg/dL) | Location | Response to steroid | OOI | Follow-up, d | Relapse | Diagnosis |
1 | Male | 28 | 69 | Diffuse | (+) | (-) | 973 | (-) | Probable type 2 AIP |
2 | Fe-male | 31 | 43 | Diffuse | (+) | (-) | 425 | (-) | Probable type 2 AIP |
3 | Male | 30 | 23 | Focal | (+) | (-) | 120 | (-) | Probable type 2 AIP |
- Citation: Ishikawa T, Itoh A, Kawashima H, Ohno E, Matsubara H, Itoh Y, Nakamura Y, Hiramatsu T, Nakamura M, Miyahara R, Ohmiya N, Goto H, Hirooka Y. Endoscopic ultrasound-guided fine needle aspiration in the differentiation of type 1 and type 2 autoimmune pancreatitis. World J Gastroenterol 2012; 18(29): 3883-3888
- URL: https://www.wjgnet.com/1007-9327/full/v18/i29/3883.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i29.3883