Weekend and nighttime effect on the prognosis of peptic ulcer bleeding

Table 1 Baseline characteristics and treatment outcomes of the weekday and weekend groups n (%)

Factors	Weekday	Weekend	P value
Number of patients	326 (84.0)	62 (16.0)
Age (yr)	60.7 ± 0.8	55.7 ± 2.1	0.023
Male	250 (76.7)	47 (75.8)	NS
Gastric ulcer	221 (68.1)	43 (69.4)	NS
Duodenal ulcer	104 (31.9)	19 (30.6)	NS
Active bleeding (Forrest Ia, Ib)	119 (36.5)	18 (29.0)	NS
Rockall score	5.0 ± 0.0	4.7 ± 0.2	NS
Charlson score	3.4 ± 0.1	3.1 ± 0.3	NS
Comorbidity	123 (37.7)	26 (41.9)	NS
Endoscopic hemostasis	309 (94.8)	57 (91.9)	NS
Time to endoscopy (min)	338.9 ± 24.9	306.8 ± 45.6	NS
Rebleeding	39 (12)	13 (21)	0.030
Angiographic embolization	4 (1.2)	1 (1.6)	NS
Surgery	3 (0.9)	1 (1.6)	NS
Length of stay (d)	8.5 ± 0.3	6.2 ± 0.5	0.009
Mortality	6 (1.8)	1 (1.6)	NS

NS: Not significant.

Table 2 Baseline characteristics and treatment outcomes of the daytime and nighttime groups n (%)

Factors	Daytime	Nighttime	P value
Number of patients	312 (80)	76 (20)
Age (yr)	60.3 ± 0.9	57.9 ± 1.7	NS
Male	238 (76.2)	59 (77.6)	NS
Gastric ulcer	209 (66.9)	57 (75.0)	NS
Duodenal ulcer	103 (33.0)	19 (25.0)	NS
Active bleeding (Forrest Ia, Ib)	111 (35.5)	26 (34.2)	NS
Rockall score	4.9 ± 0.1	4.9 ± 0.2	NS
Charlson score	3.5 ± 0.1	3.1 ± 0.3	NS
Comorbidity	119 (38.1)	30 (39.5)	NS
Time to endoscopy (min)	352.9 ± 26.3	255.0 ± 30.0	0.016
Rebleeding	36 (11.5)	16 (21.1)	0.018
Angiographic embolization	3 (0.9)	2 (2.6)	NS
Surgery	4 (1.2)	0 (0.0)	NS
Length of stay (d)	8.3 ± 0.3	7.3 ± 0.5	NS
Mortality	6 (1.9)	1 (1.3)	NS

NS: Not significant.

Table 3 Significant risk factors for mortality

Risk factor	Alive (n = 381)	Dead (n = 7)	P value
Comorbidity rate (%)	37.3	100.0	0.001
Age (yr)	59.7 ± 0.8	72.1 ± 5.3	0.037
Charlson score	3.3 ± 0.1	7.0 ± 0.7	< 0.001
Rockall score	4.9 ± 0.1	7.6 ± 0.6	< 0.001

Table 4 Subgroup analysis according to daytime and nighttime groups n (%)

	Weekday			Weekend
	Day (n = 273)	Night (n = 53)	P value	Day (n = 39)	Night (n = 23)	P value
Age (yr)	61.0 ± 0.9	58.9 ± 1.9	NS	54.8 ± 2.6	57.1 ± 3.5	NS
Active bleeding (Forrest Ia, Ib)	99 (36.3)	20 (37.7)	NS	12 (31.0)	6 (26.0)	NS
Rockall score	5.0 ± 0.1	4.9 ± 0.2	NS	4.6 ± 0.3	4.8 ± 0.4	NS
Charlson score	3.5 ± 0.1	2.9 ± 0.3	NS	2.9 ± 0.4	3.6 ± 0.7	NS
Comorbidity	102 (37.4)	21 (39.6)	NS	17 (43.6)	9 (39.1)	NS
Endoscopic hemostasis	259 (94.9)	50 (94.3)	NS	36 (92.3)	21 (91.3)	NS
Time to endoscopy (min)	355.7 ± 28.9	252.3 ± 33.0	0.020	333.7 ± 63.4	261.4 ± 60.4	NS
Rebleeding	31 (11.4)	8 (15.1)	NS	5 (12.8)	8 (34.8)	0.040
Angiographic embolization	3 (1.1)	1 (1.9)	NS	0 (0)	1 (4.3)	NS
Surgery	3 (1.1)	0 (0)	NS	1 (2.6)	0 (0)	NS
Length of stay (d)	8.6 ± 0.4	7.7 ± 0.6	NS	6.1 ± 0.7	6.5 ± 0.9	NS
Mortality	6 (2.2)	0 (0)	NS	0 (0)	1 (4.3)	NS

NS: Not significant.

Table 5 Multivariate analysis for risk factors of rebleeding

Risk factor	Rebleeding rate (%)	P value	Odd ratio	95% confidence interval
Rockall score (≥ 6)1	18	0.016	2.083	1.144-3.791
Nighttime	21	0.044	2.012	1.020-3.968
Weekend	21	0.120	1.782	0.861-3.689

¹According to the receiver operating characteristic curve, a Rockall score of 6 points was used as the cutoff value.