Expression and significance of homeodomain protein Cdx2 in gastric carcinoma and precancerous lesions

Table 1 Expression of caudal-related homeobox transcription factor in gastric carcinoma and precancerous tissues

Type	Cases	Cdx2 positive cases	%	χ2	P value
Different subtypes of intestinal metaplasia	116	101	87.1	33.826	0.000
IM (type I)	80	72	90	31.400	0.000
IM (type II)	20	17	85	7.426	0.003
IM (type III)	16	12	75	5.365	0.012
Dysplasia	72	36	50	0.004	0.873
Mild	39	17	43.5	0.083	0.700
Moderate	20	11	55	0.088	0.637
Severe	13	8	61.5	0.355	0.553
Gastric carcinoma	85	41	48.2

Cdx2: Caudal-related homeobox transcription factor; IM: Intestinal metaplasia.

Table 2 Relationship between expression of caudal-related homeobox transcription factor and clinical pathological characteristics of gastric carcinoma

Pathological parameters	n	Cdx2positive cases	Positiverate (%)	χ2	P value
Gender				0.071	0.642
Male	60	30	50
Female	25	11	44
Age (yr)				0.000	1.000
≥ 55	57	28	49.1
< 55	28	13	46.4
Lauren classification				13.544	0.001
Intestinal	43	29	67.4
Diffuse	35	9	25.7
Mixed type	7	3	42.9
Differentiation				9.991	0.001
Well and moderately differentiated	44	29	65.9
Poorly differentiated and mucinous adenocarcinoma	41	12	29.3
Depth of invasion				5.630	0.131
T1	9	7	77.8
T2	11	5	45.5
T3	25	14	56
T4	40	15	37.5
Lymph node metastasis				5.089	0.017
No	36	23	63.9
Yes	49	18	36.7
Clinical stages				5.102	0.018
I + II	19	14	73.7
III + IV	66	27	40.9

Cdx2: Caudal-related homeobox transcription factor.

Table 3 Association of various factors with overall survival by the logistic regression

Variables	B	SE	Walt	Exp (B)	P value
Cdx2	-1.290	0.397	10.586	0.275	0.001
Lymph node metastasis	0.808	0.344	5.501	2.243	0.019

Cdx2: Caudal-related homeobox transcription factor.