Mangiferin, a natural xanthone, accelerates gastrointestinal transit in mice involving cholinergic mechanism

Table 1 Effects of mangiferin and tegaserod on 6 h cumulative fecal pellet wet weight and water content in freely fed mice

Group	Dose	Fecal pellets wet weight (mg)	Water content (%)
Control (normal)	-	156.8 ± 20.98	50.46 ± 2.28
Control (vehicle)	-	161.9 ± 10.82	51.44 ± 1.19
Mangiferin	30 mg/kg, po	205.7 ± 12.69	50.31 ± 1.61
	100 mg/kg, po	245.5 ± 10.43ac	49.76 ± 3.25
	300 mg/kg, po	227.1 ± 20.11ac	49.11 ± 3.01
Tegaserod	1 mg/kg, ip	297.4 ± 7.42ac	59.20 ± 1.09ac

The results are expressed as mean ± SEM of 8 animals per group. Statistical comparison was performed using analysis of variance followed by Student Newman Keuls test.

^aP < 0.05 vs control (normal) group;

^cP < 0.05 vs control (vehicle) group.