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©2012 Baishideng Publishing Group Co.
World J Gastroenterol. May 28, 2012; 18(20): 2517-2525
Published online May 28, 2012. doi: 10.3748/wjg.v18.i20.2517
Published online May 28, 2012. doi: 10.3748/wjg.v18.i20.2517
Table 1 Baseline characteristics
Variable | Overall | Excluding patients with severe constipation | P value | |||
A (mosapride) | B (placebo) | C (mosapride) | D (placebo) | A vs B | C vs D | |
No. of patients | 124 | 125 | 108 | 120 | ||
Age (yr, mean ± SD) | 67.3 ± 8.6 | 67.8 ± 10.1 | 67.3 ± 8.5 | 67.5 ± 10.2 | NS | NS |
< 60 | 21 | 21 | 18 | 21 | NS | NS |
60-69 | 42 | 44 | 37 | 42 | ||
≥ 70 | 61 | 60 | 53 | 57 | ||
Male | 69 | 83 | 64 | 80 | NS | NS |
Female | 55 | 42 | 44 | 40 | ||
Body mass index (kg/m2, mean ± SD) | 22.5 ± 2.9 | 22.6 ± 2.7 | 22.7 ± 2.9 | 22.7 ± 2.6 | NS | NS |
Bowel movements per week | ||||||
< 2 | 16 | 5 | 0 | 0 | < 0.05 | NS |
≥ 2 | 108 | 120 | 108 | 120 | ||
Previous colonoscopy | ||||||
None (first time) | 38 | 27 | 32 | 26 | NS | NS |
≥ 2 | 86 | 98 | 76 | 94 |
Table 2 Results of the preparation and endoscopic findings
Variable | Overall | Excluding patients with severe constipation | P value | |||
A (mosapride) | B (placebo) | C (mosapride) | D (placebo) | A vs B | C vs D | |
No. of patients | 124 | 125 | 108 | 120 | ||
Time to first defecation (min, mean ± SD) | 55.4 ± 27.3 | 71.2 ± 28.6 | 52.9 ± 26.2 | 70.4 ± 28.9 | < 0.001 | < 0.001 |
Frequency of defecation (times, median, quartile) | 8.3 (4-18) | 8.6 (4-18) | 8.3 (4-18) | 8.0 (4-18) | NS | NS |
Time of bowel preparation (min, mean ± SD) | 185.1 ± 63.8 | 198.0 ± 76.5 | 178.6 ± 58.2 | 198.0 ± 76.6 | 0.11 | < 0.05 |
Elapsed time from last fluid intake to colonoscopy (min, mean ± SD) | 154.6 ± 48.9 | 154.1 ± 48.2 | 157.1 ± 63.2 | 155.5 ± 62.1 | NS | NS |
Cecal intubation rate, n (%) | 119 (96.0) | 124 (99.2) | 108 (100) | 120 (100) | NS | NS |
Insertion time1 (min, median, quartiles) | 7.8 (2-55) | 8.5 (2-38) | 7.4 (2-55) | 8.5 (2-38) | NS | NS |
Feel of peristalsis, n (%) | 20 (16.1) | 22 (17.6) | 14 (13.0) | 22 (18.3) | NS | NS |
Amount of irrigation fluid | ||||||
None | 67 | 65 | 57 | 62 | NS | NS |
< 50 mL | 40 | 47 | 33 | 46 | ||
50-100 mL | 15 | 11 | 12 | 11 | ||
> 100 mL | 2 | 1 | 2 | 1 | ||
Endoscopic findings | ||||||
Cancer | 5 | 5 | 3 | 5 | ||
Polyps | 70 | 82 | 61 | 79 | NS | NS |
Diverticulosis | 32 | 39 | 29 | 38 |
Table 3 Efficacy of overall colon-cleansing
Variable | Right colon | Left colon and rectum | P value | |||
Mosapride | Placebo | Mosapride | Placebo | Right | Left | |
No. of patients | 119 | 125 | 124 | 125 | ||
Overall score | ||||||
Excellent | 39 | 24 | 48 | 33 | < 0.05 | < 0.05 |
Good | 34 | 38 | 37 | 39 | NS | NS |
Fair | 18 | 21 | 12 | 10 | NS | NS |
Poor | 3 | 3 | 2 | 4 | NS | NS |
Inadequate | 25 | 39 | 25 | 39 | 0.07 | 0.06 |
Optimal ratings, n (%) | 91 (76.5) | 83 (66.4) | 97 (78.2) | 82 (65.6) | 0.08 | < 0.05 |
Table 4 Results of colon-cleansing efficacy excluding patients with severe constipation
Variable | Right colon | Left colon and rectum | P value | |||
Mosapride | Placebo | Mosapride | Placebo | Right | Left | |
No. of patients | 104 | 120 | 108 | 120 | ||
Overall score | ||||||
Excellent | 37 | 24 | 46 | 33 | < 0.01 | < 0.05 |
Good | 31 | 37 | 33 | 38 | NS | NS |
Fair | 16 | 20 | 10 | 9 | NS | NS |
Poor | 2 | 3 | 1 | 4 | NS | NS |
Inadequate | 18 | 36 | 18 | 36 | < 0.05 | < 0.05 |
Optimal ratings, n (%) | 84 (80.8) | 81 (67.5) | 89 (82.4) | 80 (66.7) | < 0.05 | < 0.01 |
Table 5 Results of patient questionnaire n (%)
Variable | Overall | Excluding patients with severe constipation | P value | |||
A (mosapride) | B (placebo) | C (mosapride) | D (placebo) | A vs B | C vs D | |
No. of patients | 124 | 125 | 108 | 120 | ||
Compliance > 80% | 120 (96.8) | 119 (95.2) | 105 (97.2) | 114 (95.0) | NS | NS |
100% intake | 112 (90.3) | 115 (92.0) | 97 (89.8) | 110 (91.7) | NS | NS |
Any symptom | ||||||
Nausea | 5 (4.0) | 6 (4.8) | 3 (2.7) | 4 (3.3) | NS | NS |
Vomiting | 0 | 1 (0.8) | 0 | 0 | NS | NS |
Distension | 40 (32.3) | 31 (24.8) | 31 (28.7) | 28 (23.3) | NS | NS |
Abdominal pain | 4 (3.2) | 2 (1.6) | 3 (2.8) | 2 (1.7) | NS | NS |
Circulatory reactions | 0 | 0 | 0 | 0 | NS | NS |
Willingness to repeat the same regimen | 77/115 (66.9) | 82/112 (73.2) | 67/100 (67.0) | 79/108 (73.1) | NS | NS |
How easy/difficult to take preparation compared with previous one (easy/invariable/difficult) | 34/42/10 | 24/67/7 | 32/37/8 | 23/66/5 | < 0.05 | < 0.05 |
- Citation: Tajika M, Niwa Y, Bhatia V, Kawai H, Kondo S, Sawaki A, Mizuno N, Hara K, Hijioka S, Matsumoto K, Kobayashi Y, Saeki A, Akabane A, Komori K, Yamao K. Efficacy of mosapride citrate with polyethylene glycol solution for colonoscopy preparation. World J Gastroenterol 2012; 18(20): 2517-2525
- URL: https://www.wjgnet.com/1007-9327/full/v18/i20/2517.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i20.2517