Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 14, 2012; 18(2): 119-125
Published online Jan 14, 2012. doi: 10.3748/wjg.v18.i2.119
Table 1 The features of the autoimmune hepatitis model induced by endotoxins and plant lectins
Con A[29]GalN/LPS[29]LPS[29]
(6-8 wk)(6-8 wk)(6-8 wk)
InducerCon AGalN/LPSLPS
Dosage20 mg/kgLPS: 5 μg/kg10 mg/kg
GalN: 700 mg/kg
Application methodTail veinSubcutaneousSubcutaneous
Transaminase level (max)8 h8 hNo significant change
Table 2 New drugs developed based on the Concanavalin A model
Hu 23C3[63]Monoclonal antibodyHuman osteopontinNF-κB
Anti-his H1[64]Polyclonal antibodyHistone H1NF-κB
ApoA II[65]High density lipoproteinLeukocytes and T cells-
CpG ODN[66]OligodeoxynucleotidesDNA binding ability of NF-κBNF-κB