Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection

Table 1 Clinical characteristics of patients with Helicobacter pylori infection

	7-d eradication	10-d eradication	14-d eradication	10-d sequentialeradication	Total	Pvalue
Number of patients	115	115	115	115	460
Gender						0.959
Male	60	58	62	59	239
Female	55	57	53	56	221
Endoscopic diagnosis						0.940
GU	48	52	52	48	200
DU	40	36	32	36	144
Gastritis as NUD	27	27	31	31	116
Smokers	40	36	53	44	176	0.117
Alcohol drinkers	42	48	58	56	204	0.123
NSAID/ASA	12	16	19	13	60	0.513

GU: Gastric ulcer; DU: Duodenal ulcer; NUD: Non-ulcer dyspepsia; NSAID: Non-steroidal anti-inflammatory drug; ASA: Acetylsalicylic acid.

Table 2 Helicobacter pylori eradication rates according to treatment group

	7-deradication	10-deradication	14-deradication	10-dsequentialeradication	Total	Pvalue
ITT	70.4% 81/115	74.7% 86/115	80.0% 92/115	75.6% 87/115	75.2% 346/460	0.416
PP	75.7% 81/107	81.9% 86/105	84.4% 92/109	82.0% 87/106	81.0% 346/427	0.405

ITT: Intention-to-treat; PP: Per protocol.

Table 3 Adverse events

	7-deradication	10-deradication	14-deradication	10-dsequentialeradication
Taste alterations	1	1	1	1
Loose stools	3	3	2	3
Abdominal distention	2	3	3	3
Nausea/vomiting	2	4	3	4
Epigastric discomfort	3	2	3	3
Itching	0	1	0	1
Total	11	14	12	15