Preventive effects of geranylgeranylacetone on rat ethanol-induced gastritis

Table 1 A comparison of the injury of gastric mucosa in different groups

Group	The gastric mucosa ulcer index		The epithelium damage scores
	Median	Interquartile range	Median	Interquartile range
Normal control group	0.00	0.5	0.00	1
Model control group	12.00d	4.5	4.5d	2
Low-dose model therapy group	3.50bd	1.5	2.5ad	1
High-dose model therapy group	3.00bd	1.5	2.0ad	1

^aP< 0.05,

^bP < 0.01 vs the model control groups;

^dP< 0.01 vs normal control groups.

Table 2 Comparison of the thickness of gastric mucous layer, the content of hexosamine, the content of plasma endothelin-1, serum nitric oxide and gastric mucosal prostaglandin 2 in different groups

Group	The thickness of gastric mucous layer (μm)	The content of hexosamine (mg/g protein)	Plasma endothelin-1 (pg/mL)	Serum NO (μmol/L)	Gastric mucosal PGE2 (pg/mg)
Normal control group	86.25 ± 3.21	65.57 ± 3.85	52.19 ± 2.82	30.20 ± 2.39	298.7 ± 9.28
Model control group	66.18 ± 5.11b	21.51 ± 4.54b	74.65 ± 8.84b	17.6 ± 3.37a	163.2 ± 8.84a
Low-dose geranylgeranylacetone	79.43 ± 6.67ac	31.78 ± 5.78ac	35.98 ± 4.78ad	50.60 ± 10.68c	205.7 ± 10.39c
High-dose geranylgeranylacetone	81.34 ± 5.98ac	37.78 ± 4.98ac	26.87 ± 4.87ad	69.10 ± 9.56c	265.5 ± 13.39c

^aP < 0.05,

^bP < 0.01 vs normal control group;

^cP < 0.05,

^dP < 0.01 vs model control group. NO: Nitric oxide; PGE₂: Prostaglandin 2.