Increased numbers of Foxp3-positive regulatory T cells in gastritis, peptic ulcer and gastric adenocarcinoma

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Jan 7, 2012 (publication date) through Dec 21, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 7, 2012; 18(1): 34-43
Published online Jan 7, 2012. doi: 10.3748/wjg.v18.i1.34

Table 1 Clinical characteristics of study subjects classified on endoscopy (n = 167)

	Healthycontrols	Gastritis	Pepticulcer	Gastriccancer
	(n= 22)	(n= 30)	(n= 83)	(n= 32)
Age (yr, mean ± SD)	46.4 ± 14.3	55.4 ± 15.0^a	61.7 ± 14.9^a	67.9 ± 13.9^a
Gender
Male	13	17	53	30
Female	9	13	30	2
Helicobacter pylori infection
Negative	22	20	33	21
Positive	0	10	50^b	11

^aP < 0.05, each disease vs healthy controls;

^bP = 0.02, peptic ulcer vs gastritis. Data were analyzed using the Mann-Whitney U test, χ² test and Fisher’s exact test.

Table 2 Histological grading of non-cancer subjects (n = 135)

	Healthy controls	Gastritis	Pepticulcer
Chronic inflammatory score (1/2/3)^a	21/1/0	5/5/20	1/3/79
Acute inflammatory score (0/1/2/3)^a	22/0/0/0	5/6/12/7	3/1/21/58
Lymphoid follicle number (0/1-2/≥ 3)^a	21/1/0	17/9/4	39/28/16
Helicobacter pylori density (0/1/2/3/4/5)^a	22/0/0/0/0/0	20/2/1/3/3/1	33/2/2/8/24/14
Intestinal metaplasia score (0/1/2/3)^a	22/0/0/0	10/2/4/14	22/9/20/32
Atrophy score (0/1/2/3)^a	19/1/1/1	8/9/11/2	14/40/20/9

^aP < 0.001. Data were analyzed using Kruskal-Wallis H test.

Citation: Cheng HH, Tseng GY, Yang HB, Wang HJ, Lin HJ, Wang WC. Increased numbers of Foxp3-positive regulatory T cells in gastritis, peptic ulcer and gastric adenocarcinoma. World J Gastroenterol 2012; 18(1): 34-43
URL: https://www.wjgnet.com/1007-9327/full/v18/i1/34.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i1.34