Antioxidative status of patients with alcoholic liver disease in southeastern Taiwan

doi:10.3748/wjg.v17.i8.1063

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Feb 28, 2011 (publication date) through Apr 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2011; 17(8): 1063-1070
Published online Feb 28, 2011. doi: 10.3748/wjg.v17.i8.1063

Table 1 Biochemical parameters of control subjects and patients with alcoholic liver disease (mean ± SE)

	Control	ALD
n	22	27
Male/female	19/3	23/4
Age (yr)	41.2 ± 2.1	45.3 ± 2.1
Height (cm)	169.7 ± 1.2	165.3 ± 1.3^a
Weight (kg)	66.1 ± 1.8	65.4 ± 2.3
BMI (kg/m²)	23.9 ± 0.6	23.9 ± 0.8
AST (U/L)	20.7 ± 0.9	63.6 ± 8.7^a
ALT (U/L)	22.6 ± 1.7	39.1 ± 5.2^a
AST/ALT	1.0 ± 0.06	2.86 ± 0.86^a
γ-GT (U/L)	29.2 ± 3.5	271.1 ± 81.3^a
TC (mg/dL)	185.6 ± 5.5	153.7 ± 13.2^a
TG (mg/dL)	99.4 ± 13.2	193.6 ± 61.2
HDL-C (mg/dL)	50.5 ± 3.1	36.7 ± 2.6^a
LDL-C (mg/dL)	125.5 ± 6.8	72 ± 8.2^a
Albumin (gm/dL)	4.75 ± 0.06	3.33 ± 0.18^a
Uric acid (mg/dL)	6.26 ± 0.29	6.81 ± 0.45
Total bilirubin	0.56 ± 0.04	5.53 ± 2.21^a

^aP < 0.05 vs the control group (by Student’s t-test). ALD: Alcoholic liver disease; BMI: Body-mass index; AST: Aspartate aminotransferase; ALT: Alanine transaminase; γ-GT: γ-glutamyltransferase; TC: Total cholesterol; TG: Triglycerides; HDL-C: High-density lipoprotein-cholesterol; LDL-C: Low-density lipoprotein-cholesterol.

Table 2 Erythrocytic antioxidative enzymes activities, erythrocytic reduced glutathione/oxidized glutathione ratio and plasma thiobarbituric acid reactive substances concentration of control subjects and patients with alcoholic liver disease (mean ± SE)

	Control	ALD
GPX (U/g Hb)	27.9 ± 2.2	34.4 ± 4.2
GRD (U/g Hb)	0.55 ± 0.06	0.62 ± 0.05
CAT (U/mg Hb)	11.1 ± 0.7	8.0 ± 0.7^a
SOD (U/mg Hb)	9.5 ± 1.6	3.0 ± 0.2^a
GSH/GSSG	38.1 ± 5.4	15.7 ± 1.9^a
TBARS (μmol/L)	3.5 ± 0.2	4.1 ± 0.6

^aP < 0.05 vs the control group (by Student’s t-test). ALD: Alcoholic liver disease; GPX: Glutathione peroxidase; GRD: Glutathione reductase; CAT: Catalase; SOD: Superoxide dismutase; GSH: Reduced glutathione; GSSG: Oxidized glutathione; TBARS: Thiobarbituric acid reactive substances.

Table 3 Biochemical parameters of control subjects, and non-aboriginal and aboriginal patients with alcoholic liver disease (mean ± SE)

	Control	Non-aboriginal ALD	Aboriginal ALD
n	22	12	15
Male/female	19/3	12/0	11/4
Age (yr)	41.2 ± 2.1^a	51.3 ± 2.7^b	40.5 ± 2.4^a
Height (cm)	169.7 ± 1.2^a	167.6 ± 1.6^a,b	163.6 ± 1.7^b
Weight (kg)	66.1 ± 1.8^a	66.5 ± 3.7^a	64.5 ± 3.1^a
BMI (kg/m²)	23 ± 0.6^a	23.7 ± 1.2^a	24.1 ± 1.1^a
AST (U/L)	20.7 ± 0.9^a	58.0 ± 10.7^b	68.1 ± 13.4^b
ALT (U/L)	22.6 ± 1.8^a	42.8 ± 10.0^b	36.1 ± 5.1^a,b
AST/ALT	1.0 ± 0.1^a	3.0 ± 1.4^a	2.7 ± 1.1^a
γ-GT (U/L)	29.2 ± 3.5^a	335.9 ± 173.4^b	219.3 ± 53.0^a,b
TC (mg/dL)	185.6 ± 5.5^a	157.3 ± 15.8^a	150.6 ± 21.0^a
TG (mg/dL)	99.4 ± 13.2^a	136.4 ± 66.3^a	239.4 ± 109.3^a
HDL-C (mg/dL)	50.5 ± 3.1^a	39.8 ± 4.5^b	34.3 ± 3.1^b
LDL-C (mg/dL)	125.5 ± 6.8^a	88.8 ± 13.4^b	58.5 ± 9.2^c
Albumin (gm/dL)	4.75 ± 0.06^a	3.68 ± 0.23^b	2.93 ± 0.25^c
Uric acid (mg/dL)	6.26 ± 0.29^a	6.74 ± 0.45^a	6.89 ± 0.89^a
Total bilirubin	0.56 ± 0.04^a	3.74 ± 1.43^a,b	7.31 ± 4.23^b

Values in the same row with different letters (a, b, c) significantly different at P < 0.05 (by one-way analysis of variance). ALD: Alcoholic liver disease; BMI: Body-mass index; AST: Aspartate aminotransferase; ALT: Alanine transaminase; γ-GT: γ-glutamyltransferase; TC: Total cholesterol; TG: Triglycerides; HDL-C: High-density lipoprotein-cholesterol; LDL-C: Low-density lipoprotein-cholesterol.

Table 4 Erythrocytic antioxidative enzymes activities, erythrocytic reduced glutathione/oxidized glutathione ratio and plasma thiobarbituric acid reactive substances concentration of control subjects, and non-aboriginal and aboriginal patients with alcoholic liver disease (mean ± SE)

	Control	Non-aboriginal ALD	Aboriginal ALD
GPX (U/g Hb)	27.9 ± 2.2^a	46.1 ± 7.8^b	25.0 ± 0.2^a
GRD (U/g Hb)	0.55 ± 0.06^a	0.68 ± 0.07^a	0.58 ± 0.07^a
CAT (U/mg Hb)	11.1 ± 0.7	8.5 ± 0.9^b	7.6 ± 1.1^b
SOD (U/mg Hb)	9.5 ± 1.6^a	2.9 ± 0.3^b	3.1 ± 0.3^b
GSH/GSSG	38.0 ± 5.4^a	16.5 ± 3.8^b	15.0 ± 1.6^b
TBARS (μmol/L)	3.5 ± 0.2^a	3.4 ± 0.5^a	4.6 ± 1.0^a

Values in the same row with different letters (a, b) significantly different at P < 0.05. (by one-way analysis of variance). ALD: Alcoholic liver disease; GPX: Glutathione peroxidase; GRD: Glutathione reductase; CAT: Catalase; SOD: Superoxide dismutase; GSH: Reduced glutathione; GSSG: Oxidized glutathione; TBARS: Thiobarbituric acid reactive substances.

Table 5 Biochemical parameters of control subjects, and patients with hepatitis and cirrhosis alcoholic liver disease (mean ± SE)

	Control	Hepatitis ALD	Cirrhosis ALD
n	22	10	17
Male/female	19/3	9/1	14/3
Age (yr)	41.2 ± 2.1^a	45.4 ± 4.2^a	45.3 ± 2.2^a
Height (cm)	169.7 ± 1.2^a	167.4 ± 2.3^a,b	164.2 ± 1.5^b
Weight (kg)	66.1 ± 1.8^a	70.4 ± 3.4^a	62.6 ± 3.0^a
BMI (kg/m²)	23.0 ± 0.6^a	25.2 ± 1.3^a	23.2 ± 1.0^a
AST (U/L)	20.7 ± 0.9^a	66.9 ± 18.6^b	61.7 ± 9.1^b
ALT (U/L)	22.6 ± 1.8^a	46.2 ± 12.7^b	34.9 ± 3.8^a,b
AST/ALT	1.0 ± 0.06^a	4.49 ± 2.28^b	1.9 ± 0.22^a,b
γ-GT (U/L)	29.2 ± 3.5^a	207.8 ± 71.7^a,b	308.4 ± 123.1^b
TC (mg/dL)	185.6 ± 5.5^a	188.9 ± 26.2^a	131.8 ± 11.5^b
TG (mg/dL)	99.4 ± 13.2^a	293.5 ± 153.5^b	134.9 ± 35.8^a,b
HDL-C (mg/dL)	50.5 ± 3.1^a	45.1 ± 3.8^a	31.8 ± 3.0^b
LDL-C (mg/dL)	125.5 ± 6.8^a	94.4 ± 15.8^b	58.8 ± 8.0^c
Albumin (gm/dL)	4.75 ± 0.06^a	3.87 ± 0.38^b	3.08 ± 0.17^c
Uric acid (mg/dL)	6.26 ± 0.29^a	6.68 ± 0.71^a	6.86 ± 0.59^a
Total bilirubin	0.56 ± 0.04^a	1.22 ± 0.17^a	7.48 ± 3.06^b

Values in the same row with different letters (a, b, c) significantly differ at P < 0.05. (by one-way analysis of variance). ALD: Alcoholic liver disease; BMI: Body-mass index; AST: Aspartate aminotransferase; ALT: Alanine transaminase; γ-GT: γ-glutamyltransferase; TC: Total cholesterol; TG: Triglycerides; HDL-C: High-density lipoprotein-cholesterol; LDL-C: Low-density lipoprotein-cholesterol.

Table 6 Erythrocytic antioxidative enzyme activities, erythrocytic reduced glutathione/oxidized glutathione ratio and plasma thiobarbituric acid reactive substances concentration of control subjects, patients with hepatitis and cirrhosis alcoholic liver disease (mean ± SE)

	Control	Hepatitis ALD	Cirrhosis ALD
GPX (U/g Hb)	27.9 ± 2.2^a	44.3 ± 8.6^b	28.5 ± 3.8^a
GRD (U/g Hb)	0.55 ± 0.06^a	0.74 ± 0.06^a	0.56 ± 0.07^a
CAT (U/mg Hb)	11.1 ± 0.7^a	10.8 ± 1.2^a	6.4 ± 0.6^b
SOD (U/mg Hb)	9.5 ± 1.6^a	3.7 ± 0.2^b	2.6 ± 0.2^b
GSH/GSSG	38.1 ± 5.4^a	18.3 ± 4.2^b	14.2 ± 1.7^b
TBARS (μmol/L)	3.5 ± 0.2^a	4.2 ± 1.1^a	4.0 ± 0.7^a

Values in the same row with different letters (a, b) significantly different at P < 0.05 (by one-way analysis of variance). ALD: Alcoholic liver disease; GPX: Glutathione peroxidase; GRD: Glutathione reductase; CAT: Catalase; SOD: Superoxide dismutase; GSH: Reduced glutathione; GSSG: Oxidized glutathione; TBARS: Thiobarbituric acid reactive substances.

Citation: Chen YL, Chen LJ, Bair MJ, Yao ML, Peng HC, Yang SS, Yang SC. Antioxidative status of patients with alcoholic liver disease in southeastern Taiwan. World J Gastroenterol 2011; 17(8): 1063-1070
URL: https://www.wjgnet.com/1007-9327/full/v17/i8/1063.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i8.1063