Demographic determinants of risk, colon distribution and density scores of diverticular disease

Table 1 Study sample partition by disease type, ethnicity and sex

Ethnicity sex DD site	Whites		Asians		OBs		BAs		Sub-totals by sex		Totals
	M	F	M	F	M	F	M	F	M	F
A. LSDD	114	176	3	4	5	12	2	6	126	196	322
B. RSDD	6	4	4	1	2	4	4	1	16	10	26
C. R&LDD	13	10	1	0	1	1	4	1	19	12	31
D. Pan-DD	20	26	3	2	7	5	2	3	32	36	68
No disease	150	241	24	20	34	63	11	10	219	334	553
Sub-totals by sex (all)	303	457	35	27	49	85	23	21	410	590	1000
Sub-totals by ethnicity (all)	760		62		134		44		410	590	1000
Sub-totals by sex (DD overall)	153	216	11	7	15	22	12	11	191	256	447
Sub-totals by ethnicity (DD overall)	369		18		27		23		191	256	447
Right-sided component (B+C+D)	39	40	8	3	10	10	10	5	67	58	125
(RSCDD)	79		11		20		15		67	58	125

OBs: Other blacks; BAs: Black africans; DD: Diverticular disease; LSDD: Left-sided DD; RSDD: Right-sided DD; R&LDD: Right and left DD; RSCDD: Right-sided component DD.

Table 2 Crude and adjusted associations between the odds of disease, disease subtypes and demographic parameters

	Univariate analysis		Adjusted analysis-final models
	OR/proportional odds (SE) (95% CI)	P value	OR/proportional odds (SE) (95% CI)	P value
Disease vs no disease
Asian (vs white)	0.43 (0.13) (0.25, 0.76)	0.004	0.49 (0.15) (0.27, 0.87)	0.018
OB (vs white)	0.40 (0.08) (0.27, 0.61)	< 0.001	0.43 (0.09) (0.28, 0.65)	< 0.001
BA (vs white)	1.16 (0.36) (0.63, 2.13)	0.63	1.39 (0.45) (0.74, 2.62)	0.31
Sex (F vs M)	0.88 (0.11) (0.68, 1.13)	0.32	-	-
Age (yr) (proportional odds)	1.06 (0.007) (1.04, 1.07)	< 0.001	1.06 (0.007) (1.04, 1.07)	< 0.001
	Post estimation
BA (vs Asian)	2.68 (1.10) (1.20, 5.99)	0.017	2.83 (1.21) (1.22, 6.56)	0.015
BA (vs OB)	2.87 (1.03) (1.42, 5.77)	0.003	3.22 (1.21) (1.55, 6.71)	0.002
OB (vs asian)	0.93 (0.32) (0.44, 1.74)	0.84	0.87 (0.31) (0.45, 1.79)	0.70
LSDD vs no disease
Asian (vs white)	0.21 (0.09) (0.1, 0.48)	< 0.001	0.23 (0.1) (0.10, 0.53)	0.001
OB (vs white)	0.24 (0.06) (0.14, 0.40)	< 0.001	0.25 (0.07) (0.14, 0.43)	< 0.001
BA (vs white)	0.51 (0.22) (0.22, 1.18)	0.12	0.62 (0.27) (0.26, 1.46)	0.27
Sex (F vs M)	1.05 (0.15) (0.79, 1.39)	0.75	-	-
Age (yr) (proportional odds)	1.06 (0.008) (1.05, 1.08)	< 0.001	1.06 (0.008) (1.05, 1.08)	< 0.001
	Post estimation
BA (vs asian)	2.39 (1.39) (0.77, 7.49)	0.13	2.71 (1.62) (0.83, 8.71)	0.10
BA (vs OB)	1.10 (0.53) (0.43, 2.85)	0.84	2.48 (1.26) (0.91, 6.72)	0.075
OB (vs Asian)	2.17 (1.07) (0.83, 5.70)	0.11	1.09 (0.54) (0.41, 2.89)	0.88
RSCDD vs no disease
Asian (vs white)	1.24 (0.44) (0.61, 2.50))	0.55	1.23 (0.45) (0.60, 2.54)	0.57
OB (vs white)	1.02 (0.28) (0.60, 1.75)	0.94	1.07 (0.30) (0.62, 1.85)	0.82
BA (vs white)	3.54 (1.27) (1.75, 7.16)	< 0.001	3.51 (1.30) (1.70, 7.24)	0.001
Sex (F vs M)	0.57 (0.11) (0.38, 0.84)	0.004	0.60 (0.12) (0.40, 0.90)	0.01
Age (yr) (proportional odds)	1.04 (0.01) (1.02, 1.06)	< 0.001	1.04 (0.01) (1.02, 1.06)	< 0.001
	Post estimation
BA (vs asian)	2.86 (1.36) (1.12, 7.28)	0.028	2.85 (1.39) (1.10, 7.40)	0.03
BA (vs OB)	3.46 (1.45) (1.53, 7.86)	0.003	3.30 (1.41) (1.42, 7.62)	0.005
OtB (vs asian)	0.82 (0.34) (0.36, 1.87)	0.64	0.87 (0.37) (0.36, 1.87)	0.73

OR: Odds ratio; OB: Other black; BA: Black african; LSDD: Left-sided diverticular disease; RSCDD: Right-sided component diverticular disease.

Table 3 Odds of having a higher density score in relation to disease subtype and demographic parameters

Diverticula density scores	Predictors	Univariate analysis		Adjusted analysis - Final model
		OR (SE) (95% CI)	P value	OR (SE) (95% CI)	P value
Higher vs lower	Disease type: RSCDD vs LSDD	1.91 (0.41) (1.25, 2.91)	0.003	2.77 (0.67) (1.39, 3.32)	0.001
	Asian (vs white)	0.59 (0.32) (0.21, 1.70)	0.33	0.47(0.27) (0.16, 1.43)	0.18
	OB (vs white)	0.57 (0.22) (0.27, 1.22)	0.15	0.41(0.17) (0.18, 0.92)	0.03
	BA (vs white)	0.43 (0.22) (0.16, 1.18)	0.1	0.30(0.17) (0.10, 0.88)	0.03
	Sex (F vs M)	0.98 (0.19) (0.67, 1.45)	0.92	-	-
	Age (proportional odds)	1.032 (0.01) (1.01, 1.05)	0.002	1.04 (0.01) (1.01, 1.06)	< 0.001
	Post-estimation
	BA (vs Asian)	0.72 (0.52) (0.17, 3.02)	0.66	0.73(0.47) (0.21, 2.60)	0.63
	BA (vs OB)	0.96 (0.62) (0.27, 3.40)	0.95	0.64 (0.48) (0.15, 2.79)	0.55
	OB (vs Asian)	0.75 (0.47) (0.22, 2.56)	0.65	0.87(0.58) (0.24, 3.21)	0.84

OR: Odds ratio; OB: Other black; BA: Black african; RSCDD: Right-sided component diverticular disease; LSDD: Left-sided diverticular disease.