Decreased hepatic peroxisome proliferator-activated receptor-&gamma; contributes to increased sensitivity to endotoxin in obstructive jaundice

doi:10.3748/wjg.v17.i48.5267

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Dec 28, 2011 (publication date) through Nov 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2011; 17(48): 5267-5273
Published online Dec 28, 2011. doi: 10.3748/wjg.v17.i48.5267

Table 1 Serum alanine aminotransferase, tumor necrosis factor-α, IL-1β and IL-6 levels in rats after administration of lipopolysaccharide (n = 6, mean ± SE)

	Sham	BDL	Sham + LPS	BDL + LPS
ALT (U/L)	41.2 ± 3.2	119.7±11.1^a	73.2 ± 7.7	305.0 ± 37.5^a
TNF-α (pg/mL)	27.9 ± 3.2	66.0 ± 6.5^a	861.1 ± 44.2	2364.7 ± 196.3^a
IL-1β (pg/mL)	19.7 ± 2.6	56.0 ± 7.6^a	1073 ± 97.7	2373.0 ± 265.1^a
IL-6 (pg/mL)	30.7 ± 3.5	60.2 ± 5.8^a	4476.7 ± 430.2	10802.0 ± 853.2^a

^aP < 0.01 for bile duct ligation group vs Sham group. BDL: Bile duct ligation; LPS: Lipopolysaccharide; ALT: Alanine aminotransferase; TNF-α: Tumor necrosis factor-α.

Table 2 Effect of pretreatment with rosiglitazone on serum alanine aminotransferase, tumor necrosis factor-α, IL-1β and IL-6 levels in rats after administration of lipopolysaccharide (n=6, mean ± SE)

	Sham + vehicle	BDL + vehicle	Sham + ROSI	BDL + ROSI
ALT (U/L)	78.6 ± 8.1	329.4 ± 40.5	42.3 ± 5.7^a	303.0 ± 46.6
TNF-α (pg/mL)	770.5 ± 52.5	2017.9 ± 167.5	517.0 ± 69.7^a	1984.0 ± 181.1
IL-1β (pg/mL)	1096.1 ± 101.7	2345.2 ± 194.7	648.4 ± 111.4^a	2226.7 ± 209.8
IL-6 (pg/mL)	4479.4 ± 377.4	10774.4 ± 675.4	2758.5 ± 497.7^a	9847.1 ± 865.1

^aP < 0.05 for vehicle (dimethyl sulfoxide) pretreatment vs rosiglitazone pretreatment group. BDL: Bile duct ligation; ROSI: Rosiglitazone; ALT: Alanine aminotransferase; TNF-α: Tumor necrosis factor-α.

Citation: Lv X, Song JG, Li HH, Ao JP, Zhang P, Li YS, Song SL, Wang XR. Decreased hepatic peroxisome proliferator-activated receptor-γ contributes to increased sensitivity to endotoxin in obstructive jaundice. World J Gastroenterol 2011; 17(48): 5267-5273
URL: https://www.wjgnet.com/1007-9327/full/v17/i48/5267.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i48.5267