miRNAs in precancerous lesions of the gastrointestinal tract

Table 1 miRNAs associated with different histological lesions of the gastrointestinal tract

Organ	Pathology	Overexpressed miRNAs	Downregulated miRNAs	Ref.
Esophagus	Barrett’s mucosa	miR-15b; miR-21; miR-25; miR-143; miR-145; miR-192; miR-194; miR-196a; miR-200c; miR-215	let-7a; let-7c; miR-125b; miR-203; miR-205; miR-486-5p	[30,31-33,35, 37]
	LG-IEN	miR-192; miR-196a; miR-215	let-7c; miR-203; miR-205	[32,35]
	HG-IEN	miR-15b; miR-21; miR-125b; miR-192;miR-196a; miR-200a*; miR-215	let-7a; let-7c; miR-181b; miR-193b; miR-203; miR-205; miR-486-5p	[30,31-33,35, 36]
	Neosquamous epithelium	miR-143	-	[38]
Stomach	H. pylori-related gastritis	miR-21; miR-146a; miR-155; miR-223	let-7f; miR-34b; miR-34c; miR-124a-1; miR-124a-2; miR-124a-3; miR-141; miR-200a; miR-203; miR-204; miR-455	[43,45,47,49, 50,53,56,58]
	Atrophic gastritis	-	let-7a	[55]
Colon	Traditional adenoma	miR-21; miR-135	miR-143; miR-145	[65]
	Serrated adenoma	miR-21; miR-181b	-	[70,71]
	Hyperplastic polyp	miR-181b	-	[71]
	Crohn's disease	miR-9; miR-9*; miR-21; miR-22; miR-23b; miR-26a; miR-29b; miR-29c; miR-30a; miR-30b; miR-30c; miR-31; miR-34c-5p; miR-106a; miR-126; miR-126*; miR-127-3p; miR-130a; miR-133b; miR-146a; miR-146b-5p; miR-150; miR-155; miR-181c miR-191; miR-196a; miR-223; miR-324-3p; miR-375	miR-19b; miR-629	[75,79]
	Ulcerative colitis	let-7f; mIR-7; miR-16; miR-21; miR-23a; miR-24; miR-29a; miR-29b; miR-31; miR-126; miR-126*; miR-127-3p; miR-135b; miR-223; miR-324-3p; miR-195; miR-196	miR-188-5p; miR-192; miR-215; miR-320a; miR-346; miR-375; miR-422b	[75,79]
	IBD dysplasia	miR-31	-	[80]

LG-IEN: Low-grade-intraepithelial neoplastic lesions; HG-IEN: High-grade-intraepithelial neoplastic lesions; H. pylori: Helicobacter pylori; IBD: Inflammatory bowel disease.