Copyright
©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 21, 2011; 17(47): 5221-5226
Published online Dec 21, 2011. doi: 10.3748/wjg.v17.i47.5221
Published online Dec 21, 2011. doi: 10.3748/wjg.v17.i47.5221
Table 1 Degree of cardia stenosis
Clinical classifications | Diet conditions | Cardia diameters in the barium meal exam (mm) |
I | Ordinary diet | 8-10 |
II | Semi-liquid diet | 6-8 |
III | Liquid diet | 4-6 |
IV | No drinking | 2-4 |
V | Saliva refluxing | 0-2 |
Table 2 Patient characteristics at baseline, case (%)
Characteristics | Older group | Control group |
(n = 32) | (n = 38) | |
Demography | ||
Male/female | 24 (75)/8 (25) | 29 (76.3)/9 (23.7) |
Median age, yr (range) | 79.5 (75-89) | 64 (55-74) |
Karnofsky performance status | ||
Median | 80% | 80% |
100% | 1 (3.1) | 2 (5.3) |
90% | 10 (31.2) | 13 (34.2) |
80% | 17 (53.2) | 18 (47.4) |
60%-70% | 4 (12.5) | 5 (13.1) |
Weight loss > 5% | 11 (34.4) | 13 (34.2) |
Cardia stenosis status | ||
I-II | 0 | 0 |
III | 25 (78.1) | 29 (76.3) |
IV | 6 (18.8) | 8 (21.1) |
V | 1 (3.1) | 1 (2.6) |
Histological grade | ||
G1-2 | 17 (53.1) | 19 (50) |
G3 | 12 (37.5) | 14 (36.8) |
Others (grade not stated) | 3 (9.4) | 5 (13.2) |
Extent of disease | ||
Metastatic | 10 (31.3) | 12 (31.6) |
Locally advanced | 22 (68.7) | 26 (68.4) |
Metastatic site | ||
Lymph nodes | 10 (31.3) | 12 (31.6) |
Liver | 3 (9.4) | 3 (7.9) |
Peritoneum | 1 (3.1) | 2 (5.3) |
Lung | 0 | 1 (2.6) |
Others | 0 | 0 |
No. of metastatic sites | ||
1 | 6 (18.8) | 6 (15.8) |
≥ 2 | 4 (12.5) | 6 (15.8) |
Table 3 Comparisons of chemotherapy sensitivity, case (%)
Clinical groups | CR | PR | SD | PD | CR + PR |
Older group (n = 32) | 3 (9.4) | 18 (56.2) | 11 (34.4) | 0 | 21 (65.6)a |
Control group (n = 38) | 4 (10.5) | 22 (57.9) | 12 (31.6) | 0 | 26 (68.4) |
Table 4 Comparisons of symptom (dysphagia) improvement, case (%)
Clinical groups | CR | PR | NC | PD | CR + PR |
Older group (n = 32) | 5 (15.6) | 20 (62.5) | 7 (21.9) | 0 (0) | 25 (78.1)a |
Control group (n = 38) | 5 (13.2) | 24 (63.2) | 9 (23.7) | 0 (0) | 29 (76.3) |
Table 5 Comparisons of short-term chemotherapy effects, case (%)
Clinical groups | CR | PR | SD | PD | CR+PR |
Older group (n = 32) | 5 (15.6) | 17 (53.2) | 8 (25) | 2 (6.2) | 22 (68.8)a |
Control group (n = 38) | 5 (13.2) | 20 (52.6) | 10 (26.3) | 3 (7.9) | 25 (65.8) |
Table 6 Comparisons of chemotherapy side effects, case (%)
Side effect | Older group (n = 32) | Control group (n = 38) | P1 value | ||||
I-IV | III | IV | I-IV | III | IV | ||
Leukopenia | 25 (78.1) | 3 (9.3) | 0 | 28 (73.7) | 4 (10.5) | 0 | 0.666 |
Anemia | 24 (75.0) | 2 (6.2) | 0 | 27 (71.1) | 2 (5.3) | 0 | 0.900 |
Thrombocytopenia | 23 (71.9) | 1 (3.1) | 0 | 27 (71.1) | 1 (2.6) | 0 | 0.940 |
Fever | 2 (6.3) | 0 | 0 | 3 (7.9) | 0 | 0 | 1.000 |
Oral mucositis | 13 (40.6) | 0 | 0 | 14 (36.8) | 0 | 0 | 0.746 |
Nausea/vomiting | 10 (31.3) | 0 | 0 | 11 (28.9) | 0 | 0 | 0.834 |
Diarrhea | 14 (43.8) | 0 | 0 | 16 (42.1) | 0 | 0 | 0.890 |
Fatigue | 21 (65.6) | 2 (6.3) | 0 | 23 (60.5) | 1 (2.6) | 0 | 0.660 |
Sensory neuropathy | 18 (56.3) | 0 | 0 | 21 (55.3) | 0 | 0 | 0.934 |
Liver function (ALT/AST) | 4 (12.5) | 0 | 0 | 3 (7.9) | 0 | 0 | 0.810 |
Renal function (BUN/Cr) | 1 (3.1) | 0 | 0 | 0 | 0 | 0 | - |
Hand-foot syndrome | 0 | 0 | 0 | 0 | 0 | 0 | - |
Myocardial ischemia | 0 | 0 | 0 | 0 | 0 | 0 | - |
Anaphylaxis | 0 | 0 | 0 | 0 | 0 | 0 | - |
- Citation: Gao SG, Jia RN, Feng XS, Xie XH, Shan TY, Pan LX, Song NS, Wang YF, Ding KL, Wang LD. Therapeutic effects of combined oxaliplatin and S-1 in older patients with advanced gastric cardiac adenocarcinoma. World J Gastroenterol 2011; 17(47): 5221-5226
- URL: https://www.wjgnet.com/1007-9327/full/v17/i47/5221.htm
- DOI: https://dx.doi.org/10.3748/wjg.v17.i47.5221