Moxibustion down-regulates colonic epithelial cell apoptosis and repairs tight junctions in rats with Crohn’s disease

Table 1 Comparison of current value and current flow of rat colonic epithelium in different groups (n = 10, mean ± SD)

Group	Ω/cm2	mA
NC	0.8603 ± 0.08396	58.60 ± 5.5217
MC	0.2976 ± 0.01099a	168.20 ± 6.1427a
SASP	0.4160 ± 0.01275ac	120.30 ± 3.6530ac
MWM	0.5054 ± 0.0223ace	99.10 ± 4.2804ace
HPM	0.5020 ± 0.01581ace	99.70 ± 3.1287ace

^aP < 0.01 vs normal group;

^cP < 0.01 vs model group;

^eP < 0.01 vs SASP group. NC: Normal control; MC: Model control; SASP: Salicylazosulphapyridine group; MWM: Mild-warm moxibustion group; HPM: Herbs-partitioned moxibustion group.

Table 2 Comparison of number and rate of apoptosis of rat colonic epithelial cells in different groups (n = 10, mean ± SD)

Group	Number	Rate (%)
NC	11.5 ± 4.48	0.0220 ± 0.0085
MC	61.5 ± 16.91a	0.0996 ± 0.0257a
SASP	24.7 ± 9.68ac	0.0454 ± 0.0210ac
MWM	14.8 ± 6.27cf	0.0271 ± 0.0132f
HPM	15.5 ± 8.89cf	0.0269 ± 0.0139f

^aP < 0.01 vs normal group;

^cP < 0.01 vs model group;

^fP < 0.05 vs SASP group. NC: Normal control; MC: Model control; SASP: Salicylazosulphapyridine group; MWM: Mild-warm moxibustion group; HPM: Herbs-partitioned moxibustion group.

Table 3 Expressions of occludin, claudin-1 and zonula occludens-1 in rat colonic epithelium in different groups (n = 10, mean ± SD)

Group	Occludin	Claudin-1	ZO-1
NC	1.26 ± 0.12	0.25 ± 0.04	0.28 ± 0.02
MC	0.18 ± 0.05b	0.05 ± 0.01b	0.02 ± 0.01b
SASP	0.27 ± 0.04b,c	0.08 ± 0.02b	0.05 ± 0.01b,d
MWM	0.48 ± 0.10b,d,e	0.12 ± 0.02b,d,e	0.08 ± 0.01b,d,f
HPM	0.64 ± 0.09b,d,f	0.17 ± 0.03adf	0.11 ± 0.01b,d,f,g

^aP < 0.05, ^bP < 0.01 vs normal group; ^cP < 0.05,

^dP < 0.01 vs model group; ^eP < 0.05,

^fP < 0.01 vs SASP group; ^gP < 0.01 vs MWM group. ZO-1: Zonula occludens-l; NC: Normal control; MC: Model control; SASP: Salicylazosulphapyridine group; MWM: Mild-warm moxibustion group; HPM: Herbs-partitioned moxibustion group.